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Nanotechnology Platforms for Nanoformulations

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With the development and progress of nanotechnology, the application of nanotechnology in the field of nanomedicine is becoming increasingly widespread. CD Formulation has been committed to nanotechnology research for many years, assisting researchers from various countries in the nanoformulation development and commercial manufacturing, and quality control of nanomedicines.

Advantages of Nanotechnology in Medicine

We have applied nanotechnologies in the research and development of innovative drug formulations to improve the bioavailability of drugs, increase the targeting of drugs, improve the stability of drugs, and enhance the controlled release effect of drugs.

Improve the bioavailability of drugs

Solid lipid nanoparticles serve as drug delivery systems with good tolerance, biodegradability, and improved bioavailability of oral formulations. Reducing the drug particle size and increasing the specific surface area is beneficial to the dissolution of the active ingredients of the drug. Nanomedicine has reached the level of ultra-fine powder, and the significant increase in specific surface area is conducive to the drug penetrating the gaps between tissues and improving bioavailability.

Enhance the targeting of drugs

Nanoparticles have the characteristics of long circulation, invisibility and three-dimensional stability in the body, which are conducive to increasing the targeting of drugs and are good carriers for anti-tumor drugs and anti-parasitic drugs. Nano-drug carriers can achieve targeted drug therapy.

Improve the stability of drugs

Nanotechnology can increase the shelf-life stability of drugs by maintaining their nanoform during processing or storage.

Improve the controlled release effect of drugs

Nano-controlled drug release system is an important application of nanotechnology in pharmacy. Nano-scale polymer particles are a new drug-controlled release system as a carrier for drug delivery and controlled release. Nano-controlled release systems include nanoparticles and nanocapsules. Due to the unique properties of nano-controlled release systems, they have many advantages in drug delivery, such as sustained release of drugs, prolonged drug action time, and targeted delivery.

Applications of Nanotechnology in Medicine

Nanotechnology offers the potential to advance the fields of diagnosis, detection technology, and clinical medicine through characteristics such as miniaturization, microscopic scale, small volume, minimally invasive or non-invasive procedures, rapid real-time monitoring, dynamic functionality, and intelligent capabilities. In medicine, nanotechnology has significant applications, including extensive research on drug nano-controlled release systems for novel drug delivery methods, particularly in targeted and localized drug administration, mucosal absorption drug delivery, gene therapy, and controlled release of proteins and peptides, where nanoparticles offer unique advantages.

There are multiple applications of nanotechnology in medicine, including drug delivery, disease diagnosis, targeted therapy, gene delivery, etc.

  • Synthesis of nanocarriers with integrated diagnostic and therapeutic functions
  • Targeted delivery and controlled release of diagnostic agents and therapeutic drugs
  • Preparation of new low-toxic nanocarriers with unique functions
  • Preparation of multifunctional nanocontrast agents that can be applied to different imaging modes to achieve rapid and accurate diagnosis
  • Development of biosensors to help personalized molecular medicine
  • High-resolution brain imaging to visualize neural pathways
  • Stem cell nanotechnology
  • Toxicity assessment

Fig.1 Applications of nanotechnology.Fig.1 Applications of nanotechnology in nanomedicines. (CD Formulation)

Our Nanotechnology Platforms

As a world-leading nanoformulation development and manufacturing service company, we have accumulated many years of rich experience in nanotechnology platforms in the nanomedicine field. Relying on our innovative and advanced nanotechnology platforms, such as lipid nanoparticle technology platform, albumin nanoparticle technology platform, nanocrystalline technology platform, nanoemulsion technology platform, micellar technology platform and nanoparticle technology platform, we can provide nanoformulation development and manufacturing services according to the different needs of our customers.

Why Choose Our Nanotechnology Platforms?

  • We have established multiple advanced nanotechnology platforms including lipid nanoparticle technology platform, albumin nanoparticle technology platform, nanocrystalline technology platform, nanoemulsion technology platform, micellar technology platform and nanoparticle technology platform.
  • At our nanotechnology platforms, we have accumulated rich experience and practical skills in the synthesis, preparation and characterization of nanoformulations.
  • With the help of our innovative nanotechnology platforms, we can also provide nanoformulation development and characterization services for various nanomedicines, and we also have explored some novel nanotechnology platforms in nanomedicines.

Published Data

Technology: Engineered antitumor nanoplatform

Journal: Nano Letters

IF: 10.8

Published: 2024

Results:

The authors carefully designed an antitumor nanoplatform, denoted as ZLGCR, by integrating glucose oxidase, LA oxidase, and CpG oligodeoxynucleotides into a zeolitic imidazolate framework 8 disguised with erythrocyte membranes. ZLGCR-mediated Glu and LA depletion not only enhances the effectiveness of metabolic therapy but also reverses the immunosuppressive TME, thereby enhancing the therapeutic effect of CpG-mediated anti-tumor immunotherapy. Moreover, when combined with immune checkpoint blockade therapy, the synergistic effect of metabolic therapy and immunotherapy is further enhanced. This engineered anti-tumor nanoplatform will achieve synergistic tumor suppressive outcomes by modulating metabolic and immune responses within the TME.
Here is an engineered antitumor nanoplatform:

Fig.2 An engineered antitumor nanotechnology platform.Fig.2 Construction of ZLGCR nanoplatform and schematic illustration of anti-tumor mechanism. (Ping Ji, et al. 2024)

Nanotechnology platforms are driving the broader development and application of nanomedicines. With many years of experience in nanoformulation research and development, CD Formulation has created multiple nanotechnology platforms for nanoformulation development, helping researchers make greater progress in nanoformulation research and development and preclinical research. If you are interested in our nanotechnology platforms and nanoformulation development services, please feel free to contact us.

References

  1. Ping Ji, Xiao-Kang Jin, Xin-Chen Deng, et al. Metabolic Regulation-Mediated Reversion of the Tumor Immunosuppressive Microenvironment for Potentiating Cooperative Metabolic Therapy and Immunotherapy. Nano Letters. 2024, DOI: 10.1021/acs.nanolett.4c01307.
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As a specialized brand under CD Formulation, we utilize an advanced nanotechnology platform to provide exceptional support in the creation and characterization of nanomedical solutions.

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