Nanoemulsion Technology for Nanoformulations

Nanoemulsions represent a cutting-edge technology with potential applications in augmenting the efficacy of nanomedicines through enhanced bioavailability across various therapeutic contexts. By enhancing drug solubility, stability, and delivery efficiency, nanoemulsion technologies play a crucial role in the development of innovative drug formulations. CD Formulation specializes in providing customized nanoemulsions to address specific drug delivery requirements, ensuring the stability and efficacy of the end product align with the client's specifications.

Advantages of Nanoemulsions

Nanoemulsions, ranging in size from 10 to 1,000 nm, are commonly employed as carriers for pharmaceutical compounds. These nanoemulsions can manifest in three primary configurations: oil-in-water, water-in-oil, and bicontinuous nanoemulsions. They function as effective drug delivery systems, augmenting the therapeutic efficacy of medications while mitigating adverse effects and toxic responses. Nanoemulsions are extensively utilized in the treatment of reticuloendothelial system infections, liver enzyme replacement therapy, cancer management, and vaccination. They offer advantages such as substituting liposomes and vesicles, improving drug bioavailability, exhibiting skin-friendly properties, enhancing carrier stability, featuring small droplets with high absorption capabilities, accommodating diverse dosage forms, aiding in the solubilization of lipophilic drugs, and concealing unpalatable flavors.

Applications of Nanoemulsions

Nanoemulsions possess unique properties that make them ideal carriers for delivering active pharmaceutical ingredients and bioactive substances. These properties include optical transparency, ease of preparation, thermodynamic stability, and increased surface area. Nanoemulsions find various applications in nanomedicine and drug delivery, offering benefits such as anti-inflammatory, antipyretic, antibacterial, anti-ulcer, and anti-liver and kidney disease treatments. Advancements in nanoemulsion technology have enabled the formulation of these carriers into diverse dosage forms using cost-effective standard operating procedures, including gels, creams, foams, aerosols, and sprays. Moreover, nanoemulsions can be administered through multiple routes such as orally, topically, intravenously, intrapulmonary, intranasally, and intraocularly.

Fig.1 Different applications of nanoemulsions. (Dony Lonappan, et al. 2018)

Nanoemulsion Technologies at CD Formulation

After continuous exploration and research, CD Formulation finally built our new nanoemulsion technology platform for nanoemulsion preparation and characterization.

Nanoemulsion Production Technologies

Nanoemulsions are composed of key components such as oil, emulsifier, and a water phase. These formulations typically incorporate active pharmaceuticals, additives, and emulsifiers. Various techniques are employed in the preparation of nanoemulsions, including high-energy stirring, ultrasonic emulsification, high-pressure homogenization, microfluidization, membrane emulsification, phase transition temperature, emulsion transition point, and spontaneous emulsification. Furthermore, reverse nanoemulsions can be produced in high-viscosity systems by combining high-energy and low-energy emulsification methods.

• Ultrasonic Emulsification: In this method, energy is provided through an ultrasound generator called an ultrasound probe. Ultrasound can be used directly in the production of emulsions, and it is primarily used to obtain emulsion droplet sizes as low as 0.2 μm.
• Microfluidization: This technique uses a microfluidizer to force the drug product through an interaction chamber at high pressure, resulting in very fine particles in the submicron range. We repeat this process multiple times to obtain the desired particle size, resulting in a uniform nanoemulsion.
• Phase Transition Temperature: This method changes the phase by applying a higher temperature to the microemulsion, resulting in nanoemulsions.
• Spontaneous Emulsification: We first prepare a homogeneous organic solution composed of oil and lipophilic surfactant in a water-soluble solvent and a hydrophilic surfactant and then inject the organic phase into the aqueous phase under continuous magnetic stirring to form an oil-in-water emulsion, and finally the water phase is removed by evaporation under reduced pressure to obtain nanoemulsion.

 Nanomulsion Characterization Technologies

In order to obtain a stable nanoemulsion, there should be no internal phase, no emulsification, and no microbial deterioration, and the appearance, color, odor, and consistency should meet the requirements. To ensure the effectiveness and safety of nanoemulsions and to improve their bioavailability, CD Formulation has constructed the characterization technology platform for multiple parameters of nanoemulsions such as droplet size analysis, viscometry, drug content, polydispersity, refractive index, conductivity, pH, zeta potential, etc.

Highlights of Our Nanoemulsion Technology Platform

• After careful exploration and research by our elite team, we have built two major technical platforms for the preparation and characterization of nanoemulsions to help researchers focus on the research and development of nanoemulsions.
• Based on our nanoemulsion preparation technology platform, we can choose appropriate preparation methods to provide customers with customized nanoemulsion services based on their different needs.
• We can also use our nanoemulsion characterization technology platform to provide customers with customized services while characterizing nanoemulsions to meet customer quality requirements. At the same time, we can also provide unique analysis and characterization services for nanoemulsions to customers.

Custom Nanoemulsion Development Services

Depending on our nanoemulsion technology, we can provide personalized development services for nanoemulsions to meet customers' different requirements. We have an updated and comprehensive knowledge of the distinct characteristics and applications of nanoemulsions, and we pay great attention to designing and creating personalized nanoemulsion customization solutions to ensure the robustness and clinical effectiveness of nanoemulsions, thereby promoting the application of nanoemulsions in different fields.

Published Data

With the increasing development of nanotechnology, CD Formulation has studied nanoemulsions for many years and finally built a multifunctional nanoemulsion technology platform for the preparation and characterization of nanoemulsions. This platform provides necessary assistance for nanoformulations in the field of nanoemulsion delivery and treatment. If you are looking for nanoemulsion technology services for nanoformulation development, please do not hesitate to contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.