Nanoformulation for In Vivo Imaging Studies

As nanotechnology improves by leaps and bounds, nanoformulations not only come into wide use in disease treatment and drug delivery but also are widely used for in vivo imaging. CD Formulation attaches great significance to the development and production of nanoformulation for in vivo imaging studies and has accumulated rich research experience in many years of practice. We are able to provide customers with personalized customized solutions and nanoformulation customization services for in vivo imaging studies.

Why is Nanoformulation Important for In Vivo Imaging Studies?

Nanoformulations play an active role in in vivo imaging studies due to their ability to provide larger imaging payloads, higher sensitivity, multiplexing capabilities, and modular design. Using nanoformulation-based in vivo imaging techniques, we can observe deeply into the living body, which provides great opportunities for disease diagnosis and research. In the meantime, nanoformulations have become the key to producing high-resolution, high-contrast images and are widely used for precise disease diagnosis.

At the same time, due to the physical and chemical complexity of nanoformulations, we use advanced imaging techniques to visualize the metabolic behavior of systemically administered nanoformulations in situ. Thus, the use of in vivo imaging methods in the evaluation of nanoformulations can significantly improve the efficiency of nanoformulation development, rapidly advancing clinical translation and commercial applications of nanoformulations.

Fig.1 Non-invasive imaging modalities can provide real-time monitoring of NMs fate in vivo and facilitate their clinical translation. (Ruslan G. Tuguntaev, et al. 2022)

Explore Our Nanoformulation-based Imaging Techniques

We take advantage of our advanced nanoformulation-based imaging techniques to offer anatomical, physiological, or molecular information about the in vivo systems to assist disease diagnosis.

Magnetic Resonance Imaging (MRI)

In the MRI imaging, we provide a variety of information about the body's interior, including anatomical, physiological, and even molecular information, utilizing our contrast agents (e.g., paramagnetic (Gd³⁺) and superparamagnetic (Fe₃O₄) nanoparticles).

Computed Tomography (CT) Imaging

Through CT scanners, we utilize radioactive X-rays multiple times to acquire signals from different angles and process them with computers to reconstruct three-dimensional images.

Positron Emission Tomography (PET) Imaging

We detect positron signals (gamma rays) emitted by radioactive isotopes or tracers by PET imaging to help with clinical diagnostics.

Single-photon Emission Computed Tomography (SPECT) Imaging

We detect different radioisotopes to visualize the system in the body by SPECT imaging to assist diagnostics.

Optical Imaging

In vivo optical imaging has the characteristics of non-invasive, highly sensitive, cost-effective, non-ionizing, and real-time imaging. Based on our professional knowledge and rich production experience, we fabricate plenty of best quality NIR fluorophores for in vivo imaging.

Fig.2 Incorporation of various contrast agents for multimodality imaging. (Jaehong Key, et al. 2014)

Custom Versatile Nanomaterials for In Vivo Imaging Studies

CD Formulation endeavors to gain a full understanding of the magnetic, optical, acoustic, and/or nuclear properties of nanomaterials and strives to pursue functionalized nanomaterial development.

Magnetic Nanomaterials

According to the requirements of in vivo imaging (such as using magnetic resonance imaging, magnetic particle imaging, magneto-motive imaging, and electrical impedance imaging), we customize magnetic nanomaterials based on Gd³⁺, Mn²⁺, and iron-based materials, such as gadolinium oxides (Gd₂O₃), gadolinium phosphates (GdPO₄), GdF₃:CeFn₃ nanomaterials, spherical MnO nanomaterials, hollow mesoporous silica MnO nanomaterials (HMnO@mSiO₂), iron oxide and iron alloy-based nanomaterials, conductive nanomaterials such as titania and gold, etc.

Optical Nanomaterials

Based on the performance of optical imaging, we design and produce fluorescent nanomaterials (such as quantum dots, qdots), carbon nanomaterials (such as carbon qdots), upconversion and persistent luminescent nanomaterials.

Nuclear Nanomaterials

We are keen on exploring and researching the fabrication of neclear nanomaterials for imaging, such as radioactive nanomaterials, chelated nanomaterials and intrinsically labeled nanomaterials.

Acoustic Nanomaterials

Our R&D center has also developed various nanobubbles, silica nanoparticles, and nanotubes for ultrasound imaging.

Adaptable Nanomaterials

To advance and optimize in vivo imaging techniques, we design and synthesize varieties of adaptable nanomaterials, including lipid nanoparticles, polymeric nanoparticles, liposomes, polymeric micelles, silicon-based nanomaterials, etc.

Fig.3 Nanomaterials for in vivo imaging. (Bryan Ronain Smith, et al. 2017)

Custom Nanoformulation Development Services for In Vivo Imaging Studies

Nanoformulations for in vivo imaging studies can provide important information for disease diagnosis through various in vivo imaging methods. At our multiple nanotechnology platforms, CD Formulation is committed to designing and developing various nanomaterials for in vivo imaging, meeting customers' different needs, and promoting the rapid development of disease diagnostic technology.

Why Choose CD Formulation?

• Hold versatile nanotechnology platforms for customizing class-quality nanoformulations.
• Have advanced nanomaterial-based in vivo imaging techniques to assist the disease diagnosis.
• Have extensive experience in nanoformulation evaluation.

Published Data

In vivo imaging technology can not only assist in the rational design of nanoformulations but also has great application potential in disease diagnosis. CD Formulation has researched various nanoformulations for in vivo imaging studies, based on lipid nanoparticles, liposomes, polymeric nanoparticles, metal and inorganic nanoparticles, natural nanoparticles, etc. If you are interested in our nanoformulation for in vivo imaging studies, please contact us.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.