Multilayer Tablets

Over the past years, multilayer tablets, whether as an oral immediate or a controlled-release system, have become increasingly popular. It is a delivery system that aims to deliver two or more drugs at different rates or simultaneously release. Multilayer tablets consist of a matrix core which contains the active solute(s) and one, or more barriers (modulating layers) incorporated during the tabletting process. The function of the modulating layers is to delay the interaction of active solute with dissolution medium by limiting the surface available for the solute release and at the same time controlling solvent penetration rate through the matrix.

Fig.1 Formation of multilayer tablets. (Shende P, et.al. 2012)

Fig.2 The structure of multilayer tablets. (Blicharski T, et al. 2019)

The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of multilayer tablets. CD Formulation can provide you with one-stop services to meet your needs of multilayer tablets.

Design of Multilayer Tablets:

Designing multiple layers by changing the geometry of the devices or adjustment layers allows different tablet designs for production with specific release characteristics to achieve different dissolution modes. The different designs are as follows:

• Zero order sustained release
• Quick / slow delivery system
• Time programmed delivery system

The Process of Developing Multilayer Tablets

If you have a requirement about multilayer tablets services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Shende P, Shrawne C, Gaud R S. Multi-Layer Tablet: Current Scenario and Recent Advances[J]. International Journal of Drug Delivery, 2012, 4(4): 418.
2. Yadav G, Bansal M, Thakur N, et al. Multilayer Tablets and Their Drug Release Kinetic Models for Oral Controlled Drug Delivery System[J]. ME J Sci Res, 2013, 16: 782-795.
3. Blicharski T, Swiader K, Serefko A, et al. Challenges in Technology of Bilayer and Multi-Layer Tablets: A Mini-Review[J]. Current Issues in Pharmacy and Medical Sciences, 2019, 32(4): 229-235.
4. Al-Zoubi N, Malamataris S. Three-Layer Matrix Tablets and Simple Approach of Drug Release Programming[J]. Journal of Drug Delivery Science and Technology, 2008, 18(6): 431.