Microemulsion Development Services in Drug Delivery System

Microemulsions are thermodynamically stable, isotropic, colorless, transparent or translucent dispersions of two immiscible liquids in a certain ratio in the presence of surfactants. Generally speaking, there are three types of microemulsions, namely oil-in-water microemulsion (O/W), water-in-oil microemulsion (W/O) and bicontinuous microemulsion (B.C). Microemulsions are clear and transparent thermodynamically stable systems formed spontaneously and are easy to prepare. In addition, certain components can be selectively chosen to make the system non-toxic, non-side effect and non-irritating. Based on extensive experience and technology in microemulsion development, CD Formulation's dedicated team is optimized to help you achieve milestones in drug delivery development.

Microemulsion Development Services

Microemulsions have many unique properties that make them suitable for drug delivery. CD Formulation is committed to providing a range of emulsion-based drug delivery platforms. In addition, we offer customization services for microemulsions for drug delivery. With years of experience and high-end technology, we offer products and customization services to help you achieve milestones in your drug delivery program.

Release studies of drugs in microemulsions

Release studies of drugs in microemulsions are divided into two main types: in vitro and in vivo. In vitro studies are a prerequisite for in vivo studies and provide guidance for in vivo studies. The results of in vitro studies are ultimately tested by in vivo tests. In vitro tests mainly use a classical FRANZ-type diffusion cell, which, in combination with different permeable membranes, can simulate the human environment and thus reflect the drug release process in vivo.

Factors affecting microemulsion structure and surfactant efficiency

Microemulsion domain structure is influenced both by the water-oil ratio and by the "preferred curvature" of the surfactant, which is the result of the interaction of the surfactant layer with the oil and water phases. In addition to these average curvature effects, the resistance of the surfactant interfacial layer in the microemulsion to "bending" increases with the degree of deformation. Without this effect, thermal fluctuations would cause the microemulsion interface to curl unrestrictedly, resulting in smaller and smaller microemulsion domains. These central equilibrium features of microemulsion behavior are captured qualitatively by various thermodynamic models. Many of these models describe surfactants in terms of "lipophilic strength," which is a measure of the relative affinity of surfactant molecules residing at the oil/water interface in relation to partitioning into the oil or water phase.

Microemulsion Applications

Microemulsions also have important applications in ocular drug delivery. Microemulsions are transparent, thermodynamically stable systems that are similar in appearance to ordinary eye drops. Due to the structural characteristics of microemulsions, they can solubilize various drugs, which is important for drugs with low solubility. Microemulsions can also enhance the stability of drugs and improve the bioavailability of drugs. Currently, more researchers are trying to make use of the special structure of microemulsions to make microemulsion-based drug carriers into a carrier system capable of slow release of drugs in the eye and targeted release of drugs.

CD Formulation can provide you with professional microemulsion development customization services to provide exclusive solutions for your projects. If you are interested in our services, please do not hesitate to contact us.