Liposome Formulation for Tissue Engineering Research
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Tissue engineering, also known as regenerative medicine, aims to develop biologically active implants capable of repairing or enhancing tissue defects in structure and function. Tissue engineering and regenerative medicine typically involve the reconstruction of cells, tissues, or organs to restore normal biological characteristics. In recent years, the tissue engineering field has benefited from various new technologies (especially liposome technology) and experienced rapid development. At CD Formulation, we specialize in developing customized liposome formulations to support tissue regeneration research.
Advantages of Liposome Systems in Tissue Engineering
- Biocompatibility: Liposomes are biodegradable, non-toxic, and non-immunogenic.
- Versatile Drug Delivery: Capable of encapsulating hydrophilic and lipophilic drugs, liposomes enable controlled release, reducing side effects.
- Targeted Delivery: Functionalized liposomes with ligands ensure precise, site-specific drug targeting.
- Protection: Liposomes safeguard active compounds from degradation and clearance.
- Customizable Properties: Liposomes offer flexible physical and chemical attributes to meet diverse delivery challenges.
- Natural Composition: Made from natural materials, ensuring safety and compatibility.
Fig.1 Tissue defects and regeneration. (A) Categories of tissue defects. (B) Currently applied strategies for tissue regeneration. (E Natsaridis, et al, 2021)
Main Applications of Liposomes in Tissue Engineering Research
| Applications |
Case Studies |
- Dental Tissue Engineering. Liposome hydrogels, suitable for injection, are utilized in dental tissue engineering.
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LCH and HCH loaded with Lip/Cur+Toc are promising candidates with multi-functional features for endodontics and periodontics.
Fig.2 Injectable liposome hydrogels employed for dental tissue applications. (Atila D, et al, 2024) |
- Nerve Regeneration. Controlling the immune microenvironment surrounding central nervous system neurons presents a formidable challenge. A promising strategy to address this critical issue involves drug-loaded scaffolds, which can deliver drugs directly to neighboring cells while bypassing the blood-brain barrier and the blood-spinal cord barrier.
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The CDPC-liposome composite scaffold shows greater potential in suppressing the inflammatory response of microglia cells and facilitating axon elongation, thus holding promise for applications in the field of nerve repair.
Fig.3 The illustration of Liposomes for nerve regeneration. (Lin, J., et al, 2021) |
- Wound healing. Due to the intricate nature of chronic ulcer healing, meticulous consideration must be given to the selection of biomolecules, delivery materials, and dressings based on their consistency and biological characteristics. For example, liposome delivery systems can be employed to address the multifaceted challenges presented by chronic wounds, as they possess all essential attributes for promoting wound healing.
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Fig.4 Growth factors-based delivery approaches for chronic wound repair and regeneration. (Sharma P., et al, 2021) |
- Osteanagenesis. Although metal implants are the most widely used biomaterial in orthopedic surgery, they do not induce new bone growth due to their bioinert nature. Surface biofunctionalization of implants with immunomodulatory mediators is the latest method to promote osteogenic factors to promote bone regeneration. Liposomes can be used as a low-cost, efficient, and simple immunomodulator to stimulate immune cells and contribute to bone regeneration.
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A mechanically enhanced liposome-GelMA hydrogel can represent an excellent solution for osteanagenesis.
Fig.5 Liposome-GELMA hydrogel can control the release of bone regeneration drugs and enhance mechanical properties. (Elkhoury, Kamil, et al, 2020) |
Our Capabilities in Liposomal Tissue Engineering Research
- Targeted Delivery Solutions: Expertise in designing and synthesizing liposomal carriers for specific tissue targeting, with innovative encapsulation methods for bioactive molecules.
- Biocompatibility and Safety Studies: Extensive research on the safety and biocompatibility of liposomal formulations for various applications, including regenerative medicine and organ repair.
- Advanced Analytical Technologies: Utilization of nanoscale characterization, advanced imaging, and computational modeling to optimize liposome behavior in biological environments, facilitating more effective tissue engineering solutions.
Explore Our Services for Liposomal Tissue Engineering Research
Injectable Liposome Formulation Development
Our services cover the entire R&D process of injectable liposome development, including formulation design and screening, in vitro pharmacodynamic evaluation, testing phase and mass production challenges.
Custom Long-circulating Liposome Service
We can provide modification services for derivatives, and colleagues can provide PEG-modified liposomes with different chain lengths. we help our customers explore more alternative long-circulating liposomes to PEG modifications that avoid the ABC effects caused by such PEG liposomes.
Universal Liposome Characterization
We offer comprehensive characterization services for these parameters: such as liposome morphology, surface characteristics, structure and integrity, charge distribution, drug encapsulation efficiency, phase transition temperature, particle size distribution, etc.
Custom Polymer-modified Liposome Service
We provide screening services and provide the polymer or copolymer, polymer derivatives, including, chitosan, atelocollagen, modified xanthan gum department, alginate, cyclodextrin, gelatin, poly (acrylic acid), etc.
Custom Reactive Oxygen Species (ROS)-responsive Liposome Service
Our ROS-responsive liposome development platform enables the formulation of functional liposomes for different disease research, including research for atherosclerotic lesion areas, tumor drugs, diabetes complications, Cardiac repair disorders after myocardial ischemia-reperfusion (MI/R) injury, etc.
As a leader in liposome technology, CD Formulation is dedicated to supporting tissue engineering innovations through customized liposome R&D services. Contact us for tailored solutions to advance your research.
References
- Natsaridis E, Mouzoura P, et al. Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration. The International Journal of Developmental Biology. 2021 Aug 9;66(1-2-3):137-54.
- Atila D, Dalgic AD, et al. Injectable Liposome‐Loaded Hydrogel Formulations with Controlled Release of Curcumin and α‐Tocopherol for Dental Tissue Engineering. Advanced Healthcare Materials. 2024 Jun 7: 2400966.
- Lin, J., Song, X., et al. Citicoline–liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration. J Mater Sci. 2022. 57, 2073–2088.
- Sharma P, Kumar A, et al. Stem cells and growth factors-based delivery approaches for chronic wound repair and regeneration: A promise to heal from within. Life sciences. 2021 Mar 1; 268: 118932.
- Elkhoury, Kamil; Kocak, Polen, et al.Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery. Pharmaceutics. 2020. 12. 849. 10.3390.
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