Liposome Formulation for Parasitic Diseases and Infections Research

Liposomes have shown significant potential in combating various parasitic diseases, including malaria, leishmaniasis, and Chagas disease. They are also effective carriers for antifungal medications, treating systemic fungal infections like those caused by Candida albicans and Aspergillus fumigatus, with greater effectiveness and lower toxicity compared to traditional drugs. CD Formulation focuses on advancing the use of liposomes for anti-parasitic and anti-infective research through our robust platform and technologies.

Advantages of Liposome Systems in Infectious Disease Research

Liposomes play a crucial role in the development of drug formulations for parasitic, bacterial, and fungal infections. The liver, often a target for parasites, can be effectively targeted using liposomal delivery systems. Liposomes offer enhanced drug delivery with the following benefits:

• Targeted therapy: Liposomes can deliver drugs to specific organs or sites, thereby improving therapeutic effects and reducing toxicity. For example, liposomes can bind to antibodies, proteins, or enzymes and deliver bioactive compounds directly to the infected site.
• Improved stability: Liposomes can encapsulate drugs to prevent them from degrading in the body, thereby improving the bioavailability of drugs and addressing issues such as poor solubility and low permeability in water.
• Controlled release: Liposomes can release drugs in a controlled manner, helping to slow the progression of resistance.
• Synergistic effects: Liposomes can enhance the efficacy of anti-parasitic drugs without causing toxicity to host cells. For example, liposomes can deliver antigens as vaccine candidates to elicit a strong immune response to clear infections.
• Multiple administration routes: The administration routes are diverse, including oral, transdermal, and intranasal administration methods.

Fig.1 Schematic representation of the main advantages of liposomes as antibiotic carriers. (Ferreira M, et al, 2021)

Main Applications of Liposomes in Parasitic Diseases and Infections Research

Liposomal-encapsulated antibiotics demonstrate efficacy against infections caused by facultative intracellular bacteria, parasites (such as Leishmania), and viruses (such as the virus responsible for Rift Valley fever). CD Formulation provides specialized liposome solutions for research on parasitic diseases and infections.

Therapy and Targeted Delivery	Case Studies
Treatment for Malaria. Malaria parasite resistance and toxicity of antimalarial drugs pose a challenge to treatment. We utilize liposomal controlled release techniques and try to offer solutions to address these limitations.	Fig.2 Reparation and assessment of liposomes targeting the brain for anti-malarial therapy. (Tian, Ya, et al, 2022)
Leishmaniasis.One of the primary challenges in treating leishmaniasis is the difficulty in targeting drugs to the infected area. Leveraging liposome targeting technology enables us to offer a wider range of potential solutions to this issue.	Fig.3 Preparation and assessment of liposomes targeting the brain for anti-malarial therapy. (Tambe S, et al, 2024)
Chagas Disease. Chagas disease drugs have limited effectiveness due to poor cell entry, but liposomes may improve insoluble drug delivery. We are trying to alleviate this limitation with the advantages of liposomes in insoluble drugs.	Fig.4 In vivo mechanism for Chagas disease. (Machado, Fabiana., et al, 2012)
Human African Trypanosomiasis. Currently, the treatment options for HAT have limitations and side effects, so there is an urgent need to explore new therapies.	Fig.5 Nanocarriers proposed for the delivery of PTM in different therapeutic approaches. (Machado, Fabiana., et al, 2022)

Vaccines	Specific Cases
Liposomes are used to create new vaccines that boost immune responses, targeting specific T cell subsets and enhancing mucosal or systemic immunity by combining recombinant antigens with modulating adjuvants.	Fig.6 Various modes of liposome-antigen association. (Giddam, Ashwin Kumar, et al, 2012)

Diagnostics

Case Studies

Currently, nanoparticles or liposome carriers have demonstrated efficacy in parasite diagnosis. Diagnosis of malaria. For example, gold nanoparticles functionalized with antibodies targeting malaria biomarkers (such as HRP2) are utilized for early detection and diagnosis of malaria. Diagnosis of leishmaniasis. Liposomal amphotericin B, another successful case, can be employed for confirming the diagnosis of leishmaniasis following serological or skin tests.

Fig.7 Chunap (Chagas urine nanoparticle assay) assay for the early diagnosis of congenital Chagas disease. (Quijia, Christianr, et al, 2019)

Our Capabilities on Liposomal Drugs for Parasitic Diseases and Infections Research

Fig.8 Our capabilities on parasitic diseases and infections research. (CD Formulation)

CD Formulation offers a range of services to support your research:

• Targeting technology: Expertise in both active and passive targeting, including long-cycle liposomes, glycosylated modifications, immune liposomes, and responsive technologies.
• Formulation Development: Comprehensive support from initial R&D to formulation optimization.
• Multiple Drug Delivery Routes: Proficient in developing liposome formulations for inhalation, oral, and transdermal delivery.
• Controlled Release Technology: Combining exogenous stimuli with liposome release mechanisms for efficient drug delivery.
• Liposome Characterization: In-depth evaluation of in vitro release, cytotoxicity, cell uptake, size, encapsulation efficiency, and stability.
• Solvent Removal Techniques: Utilizing gel filtration, vacuum evaporation, centrifugation, dialysis, and nitrogen blow technology to eliminate organic solvents effectively.

Explore Our Liposome Services for Anti-Parasitic and Anti-Infective Research

As a leader in liposome technology, CD Formulation is dedicated to providing researchers with advanced liposomal solutions to further the development of effective treatments against parasitic and infectious diseases. Contact us to learn how we can assist with your research needs.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.