Functionalized Carbon Nanotube Modifications

Carbon nanotubes (CNTs) can be classified into single-walled carbon nanotubes and multi-walled carbon nanotubes. each carbon atom in CNTs is bonded with sp2 bonds, which are stronger than the sp3 bonds in diamond, giving CNTs unique physicochemical properties such as easy surface modification, ability to enter cells, good biocompatibility, and non-immunogenicity. Carbon nanotubes are effectively taken up by many different types of cells through a variety of mechanisms. Carbon nanotubes are easily surface functionalized and can be used as carriers for anti-cancer molecules, paclitaxel (PTX) and gemcitabine (GEM)), anti-inflammatory drugs, etc.

Advantages of Carbon Nanotubes

• Better biocompatibility, lower cytotoxicity, unique physicochemical properties.
• Larger internal volume for loading more biomolecules than spherical nanoparticles, and the external surface can be chemically modified to obtain more new properties.
• Can transport biomolecules across cell membranes to target cells via endocytosis.
• Has the activity of inducing cell death.

Functionalization Services of Carbon Nanotubes

CD Formulation has long focused on the development of drug formulations and optimization of drug transport, helping customers to solve problems encountered in the process of product development. Based on the special properties of carbon nanotubes, we can modify them functionally to expand their applications in the medical field.

Functionalized carbon nanotubes can have altered surface properties that increase their dispersibility, homogeneity and solubility. Our pharmacy professionals have many years of experience in functionalized modification of drug transport systems. By introducing different groups to the sidewalls and ends of carbon nanotubes, biomolecules such as peptides, proteins, nucleic acids and drugs can be coupled to CNTs through covalent or non-covalent interactions, which can target tissues and organs at focal sites for the purpose of treating diseases.

Covalent Functionalization Modification Method

The most common method of covalent functionalization is to generate carboxyl groups on the surface of CNTs by oxidizing them with strong acids; the carboxyl groups on the surface of CNTs are modified by adding compounds containing free amino groups after reacting with thionyl chloride; through covalent modification, different alkyl chains or terminal functional groups can be prepared to generate different CNTs complexes, thus enhancing the biocompatibility and targeting properties of CNTs.

Non-Covalent Functionalization Modification Method

Non-covalent functionalization of CNTs is based on different modes of action such as π-π conjugation, hydrogen bonding, electrostatic, van der Waals forces and hydrophobic interactions by surfactants, aromatic compounds, polymers, etc.

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.