Effervescent Tablets

Effervescent tablets are tablets when added in water release carbon dioxide. They are products that compress the components in the form of powder into compact lumps. They dissolved rapidly in water due to the chemical reaction which takes place between alkali bicarbonate and citric acid or tartaric acid or combination of both. Therefore, these tablets should be protected from atmospheric moisture during storage, it should be packed in a blister package or a sealed desiccant in a bottle cap and put into the desiccant.

Fig.1 Packaging must completely protect the effervescent tablets from water vapor or they may self-destruct.

The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, so CD Formulation can provide you with complete solutions for the effervescent tablets. Even if it contains bitter, sulfuric, sour, metallic, astringent or difficult to process APIs, we will design and manufacture effervescent tablets with pleasant taste to meet your needs. All our effervescent products can be quickly and completely dissolved without residue or foam.

Our Granulation Technological

• Dry methods
• Wet granulation
• Organic solvents
• Fluid bed spray granulation

The Process of Developing Effervescent Tablets

Effervescent tablets are produced in much the same manner as conventional tablets, but production must occur in very low humidity areas.

Material Handling: an active substance or a combination of active substances are mixed with sweeteners, fillers and colouringsas well as with flavours in a high shear mixer.

Granulation & Drying: the material fed into the presses produced must as equal weight and homogeneous. They compressed in high-speed rotary presses. Wet granulation is avoided, because it may initiate the reaction. Roller compaction and direct compression are used for drying.

Add Lubricants: it is common practice in effervescent tablet production to add a lubricant after granulation; the most commonly used substance is magnesium stearate.

Tablet Compression: the compression of effervescent tablets is different from the compression of normal tablets. For long-term storage, a very low moisture content is required-typically less than 0.3% water compared with approximately 2% for traditional tablets.

Packaging: after the material has been pressed into tablets, the surface area of the material has been significantly reduced, which means that the rate at which moisture is absorbed from the air has also been reduced. Commonly, the dehumidification of the environmental air is now less critical. Blisters and tube arrangements are used for packaging.

If you have a requirement about effervescent tablets services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Robert E L. Effervescent Tablets, Key Facts About A Unique, Effective Dosage Form. Amerilab Technologies[J]. 2001.
2. Lopatin A, Bellussi L, Mladina R, et al. Effervescent Tablets: A Safe and Practical Delivery System for Drug Administration[J]. International Scientific Advisory Board, 2016.
3. Patel S G, Siddaiah M. Formulation and Evaluation of Effervescent Tablets: A Review[J]. Journal of Drug Delivery and Therapeutics, 2018, 8(6): 296-303.