Creams

The cream is a semisolid emulsion containing a mixture of oil and water. Their consistency is different between liquid and solid. The development of cleansing cream and cold cream was promoted by early ointment (soothing ointment) and non irritant (soothing product) preparations, and due to the development of new technology such as emulsifier and other additives, the preparation of cream has become very easy.

Fig.1 Cream. (Lecheb F, et al. 2015)

The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of creams. CD Formulation can provide you with one-stop services to meet your needs of creams.

The Properties of Creams

• Easy to apply
• Easy to spread on the skin
• Cause less irritation to the skin
• Form an emollient film on the skin after application
• Melt or liquefy when applied on to the skin

Basic Raw Materials Used in the development of Various Creams

• Fatty acid.
• Hydrocarbon
• Hydrocarbon waxes
• Oleoginous Substances
• Fatty acid & alcohols
• Emulsifiers

The Process of Developing Ointments

There are several factors to consider when preparing cream:

• Emulsion type selection

Oil in water emulsion is used for local application of water-soluble drugs, mainly for local effect. They do not have the greasy texture associated with oily matrix, so they are comfortable to use and easy to clean from the skin surface.

• Selection of oil phase

Many topical lotions contain oil as a carrier of active ingredients. It must be recognized that the type of oil used may also have an impact on the viscosity of the product and the transport of the drug to the skin. One of the most widely used oils for this type of preparation is liquid paraffin.

• Selection of emulsifier

The choice of emulsifier used depends on its emulsifying ability, route of administration, toxicity and other factors. Most nonionic emulsifiers are less irritating and less toxic than their anionic and cationic counterparts. Some emulsifiers, such as ionic alkaline soaps, usually have a higher pH value and are therefore not suitable for use on damaged skin.

If you have a requirement about creams services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Lecheb F and Benamara S. Feasibility Study of A Cosmetic Cream Added with Aqueous Extract and Oil from Date (Phoenix dactylifera L.) Fruit Seed Using Experimental Design[J]. Journal of Cosmetic Science the Official Journal of the Society of Cosmetic Chemists, 2015, 66: 1-12. 
2. Shahlla I, Najma S, Farhana T, et al. Evaluation of Anti-Inflammatory and Other Biological Activities of Flavonoid Based Cream Formulation for Topical Application Using in Vitro Model[J]. Journal of Cosmetic Science the Official Journal of the Society of Cosmetic Chemists, 2017, 8(10): 4388-4395.
3. Kashmira K and Harsha K. Film Forming Systems for Topical and Transdermal Drug Delivery[J]. Asian Journal of Pharmaceutical Sciences, 2017, 12(6): 487-497.