Colloidosomes System Development

The high degree of control over physical properties makes colloidosomes attractive structures for the encapsulation and controlled release of substances ranging from fragrances and active ingredients to molecules produced by living cells. CD Formulation is dedicated to the discovery and design development of drug delivery systems, and we are confident that we can provide the best service and products to our customers around the world. Our advanced technology equipment and quality service will help you win the success of new drug delivery preparations.

Fig.1 The image of colloidosomes. (Thompson et al., 2015)

Carriers for Drug Delivery

The use of colloidal and nanoparticle carrier systems in the biomedical field has changed the definition of diagnosis, therapy and disease management. Vesicular systems are used for the sustained release of drugs, pesticides, fragrances and other substances. Among a range of vesicular systems, colloidosomes are emerging as potential tools for controlled delivery of drugs, cosmetics and food supplements.

Colloidosomes System Development

As a leading global service provider, CD Formulation specializes in the field of lipid drug delivery. Based on our advanced platform and extensive experience, we are now able to provide individual colloidosomes build services and commercial deliverables to our customers.

Characterization Testing

CD Formulation can provide customers with characterization of colloidosomes including particle size determination, zeta potential determination, gravimetric separation, small droplet concentration determination, optical microscopy, surface morphology analysis, etc. Other physicochemical property tests offered by CD Formulation include drug encapsulation rate and colloidosomes loading capacity testing.

Characterization Instruments

• Particle size and zeta potential measurements
• X-ray photoelectron spectroscopy (XPS)
• Microscopy techniques
• Transmission electron microscopy (TEM) of ultra-thin sections
• Differential scanning calorimetry (DSC)
• Freeze-Etch Electron Microscopy

What else can we do?

As a lipid granule drug delivery system, colloidosomes has been widely used in drug delivery. As a biological company with a full range of products and services, CD Formulation can supply you with a wide range of liposome and other liposomal drug carrier preparations, both empty and embedded, as well as related services, including characterization and validation, science and detailed requirements based on customer applications.

Applications of the Colloidosomes System

Colloidosomes are hollow, elastic shells whose permeability and elasticity are controlled. It is a new class of microcapsules whose shell consists of colloidal particles solidified or fused at the emulsion droplet interface. Colloidosomes can be used in the following therapeutic and pharmaceutical applications:

Drug/protein delivery vector

Drug control and sustained release

Enhanced drug solubilization

Changes in pharmacokinetics and biodistribution

Enzyme encapsulation

Tumor therapy

Eye drug delivery

Brain delivery

DNA delivery

Enzyme immobilization

Potential Benefits of Colloidosomes

a. Colloidosomes is a multifunctional technology that provides efficient packaging structures with easy control over size, permeability, mechanical strength, and compatibility.

b. Through control of colloidosomes mechanical strength, the yield stress can be adjusted to withstand different mechanical loads and is released by prescribed shear rates.

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. We are glad to be your partner in the field of liposome research and are willing to provide you with first-class liposome services. If you are interested in our services, please do not hesitate to contact us promptly.

Reference

1. Thompson, K. L., et al. (2015) Colloidosomes: synthesis, properties and applications. Journal of colloid and interface science, 447, 217-228.