In the dynamic field of drug delivery systems, transdermal coated microneedle patches are transforming how medications are administered. This innovative approach leverages precision-engineered microneedles coated with active substances to provide a non-invasive, efficient, and effective solution for medication delivery. CD Formulation offers professional services for developing customized transdermal coated microneedle patches tailored to researchers' specific needs.

About Transdermal Coated Microneedle Patches

Coated microneedles, also known as surface-loaded microneedles, feature a layer of medication applied via techniques such as infiltration, coating, or external loading. Once inserted into the skin, the microneedles dissolve, releasing the drug into the intercellular fluid, facilitating fast absorption and high bioavailability. Suitable for delivering both small and large molecule drugs, the coating process ensures controlled dosage and stability. However, the coating's thickness and needle surface area are crucial to maintaining consistent drug delivery.

Fig.1 Schematics describe how coated microneedles facilitate delivery of active materials into the skin. (Rohan S.J. Ingrole, et al. 2021)

Key Advantages of Transdermal Coated Microneedle Patches

Microneedles, with their micron-scale size, painlessly penetrate the stratum corneum, enabling efficient drug administration. They combine the efficacy of hypodermic needles with the ease of a transdermal patch, offering benefits like:

• Minimally invasive and painless delivery
• Fast and efficient drug release
• High bioavailability and easy dose control
• Compatibility with water-soluble, small, and large molecule drugs

CD Formulation focuses on delivering cutting-edge coated microneedle technology that maximizes these benefits, ensuring seamless drug application for various compounds.

Customized Development of Transdermal Coated Microneedle Patches

Microneedle Design

• Custom Design: Tailoring the size, shape, and arrangement of microneedles for effective and comfortable skin application.
• Material Selection: Choosing suitable materials (e.g., silicon, polymers, metals) based on drug properties and biocompatibility requirements.

Microneedle Manufacturing Techniques

• Microelectromechanical Systems (MEMS): Crafting microneedles using precise lithography and etching for enhanced structural accuracy.
• Mold-Based Fabrication: Producing microneedle arrays from plastic or polymer through injection molding or imprinting.

Drug Formulation Design

Selecting suitable drugs and carrier materials (such as polymers, liposomes, etc.) and formulate drug carrier solutions to ensure the stability and effective release of drugs on the microneedles.

Our Coating Technology and Materials

Coating Technology

To effectively coat drug molecules on microneedle surfaces, CD Formulation employs various methods, including dip coating, inkjet coating, spray coating, and more. These techniques are carefully selected to achieve uniform, stable, and effective coatings.

Fig. 2. Coating Technology. (CD Formulation)

Coating Materials

• Excipients: Used to adjust the viscosity and surface tension of coating solutions, including polyvinylpyrrolidone, polyphosphazene, and carboxymethyl cellulose.
• Stabilizers: Added to protect active molecules (e.g., proteins, inactivated viruses) from denaturation, using substances like arginine, glucan, and maltodextrin.

Why Choose CD Formulation?

• We use the most advanced microneedle manufacturing technology, including photolithography, injection molding, and film deposition processes, to ensure the precision and consistency of microneedles.
• We also use the latest technologies in drug coating, such as spraying, dipping, and film coating, to ensure the stability and effective release of drugs on the microneedles.
• During the design and manufacturing process, we focus on the stability and durability of the patch, ensuring that its drug release effect is not affected during storage and use, thus providing reliable delivery outcomes.

Published Data

CD Formulation continues to innovate in the field of transdermal coated microneedle patch development, setting new standards for precision and reliability. For customized development solutions, contact us, and we will respond within three business days.