Energy-driven Technology for Transdermal Delivery

Traditional transdermal drug delivery is hindered by the skin's natural barrier, often resulting in limited drug absorption. CD Formulation has pioneered an energy-driven approach, integrating advanced technologies like ultrasonic, electroporation, and intermediate-frequency pulses. These methods, combined with a smart control system, significantly enhance drug delivery efficiency, enabling deeper penetration into tissues and creating high-concentration areas for therapeutic effects. This innovative approach supports pharmaceutical development projects by offering enhanced drug delivery.

About Energy-driven Technology

The energy drive method uses various forms of energy (such as sound energy, electrical energy, heat energy, etc.) through physical, chemical, and other ways to promote or enhance a specific process or reaction method. In the medical field, the energy drive method has been widely used in many aspects such as transdermal drug delivery, physical therapy, and surgical assistance. A main challenge in transdermal drug delivery is the skin's stratum corneum. It blocks drugs from being absorbed. Its stable properties prevent large molecules from penetrating. The energy drive method can effectively increase the skin's permeability through physical means such as ultrasound, electroporation, and intermediate frequency pulse so molecules can more easily penetrate the skin barrier and enter the deep tissue.

Explore Our Energy-driven Technology Platform

At CD Formulation, the technologies for enhanced transdermal drug delivery with an energy-driven method include the following:

• Iontophoresis: Ionic drugs were transported through skin biofilms by the principle of electromigration under the action of the electric field.

Fig.1 Schematic diagram illustrating the delivery mechanism of cationic drugs using iontophoresis. The black arrows in the skin describe the flow of cationic drug moves from the drug solution to the cathode. Conversely, the white arrows show the movement of anions from the buffer solution under the cathode to the anode. (Delly Ramadon, et al. 2021)

• Sonophoresis: By using the thermal effect, cavitation effect, and flow effect produced by ultrasound, the metabolism of skin tissue is accelerated, and the permeability and bioavailability of drugs are improved.

Fig.2 A schematic illustration of sonophoresis-assisted transdermal drug delivery. Following the application of ultrasound, the drug molecules will be delivered into the dermis. (Delly Ramadon, et al. 2021)

• Electroporation: By applying a short high-voltage electrical pulse on the skin, the lipid bilayer of the stratum corneum forms a temporary hydrophilic pore, thereby enhancing and promoting the penetration of drug molecules.

Fig.3 Schematic diagram illustrating transdermal drug delivery using the energy-driven electroporation method. Electroporation helps the drug to permeate into the dermis layer. (Delly Ramadon, et al. 2021)

Characteristics of Energy-driven Methods

Fig.4 Characteristics of energy-driven methods. (CD Formulation)

What Transdermal Formulations Can We Develop?

CD Formulation uses the energy-driven method to develop many types of transdermal formulations for researchers. These include, but are not limited to:

Our Expertise in Energy-driven Drug Delivery

• Rich project experience: In the field of energy drive technology, our company has completed several research and development projects and accumulated rich project experience.
• Advanced experimental equipment: Our company is equipped with international first-class experimental equipment, including high-precision electroporation instruments, ion electroosmosis instruments, ultrasonic import instruments, etc. This equipment provides strong hardware support for research and development work.
• Professional R&D team: Our company has a professional R&D team, and they have a deep theoretical foundation and rich practical experience in the field of energy drive technology.

Publication Data

Energy-driven transdermal drug delivery methods present clear advantages in overcoming the skin barrier. CD Formulation is dedicated to advancing this technology through continuous R&D, collaborating with leading medical and research institutions globally. Our solutions are designed to meet the needs of researchers and pharmaceutical developers, providing comprehensive, efficient services for optimized drug delivery. Contact us if you have any needs. Our team will reply within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.