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Proteins & Peptides Innovative Delivery System Delivery Development

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CD Formulation is one of the leaders in developing innovative drug delivery systems for proteins/peptides. We excel in encapsulating proteins/peptides in various excellent drug carriers to improve their stability, solubility, and bioavailability. With advanced technology and a professional team, we provide customers with customized solutions, including but not limited to nanoparticles, liposomes, microcapsules, hydrogels and other delivery systems.

Importance of Developing Innovative Drug Delivery Systems for Proteins and Peptides

Therapeutic proteins and peptides have become a hot topic in recent years due to their high efficacy and few side effects. However, these active drug molecules are relatively unstable and have limited permeability to the epithelium and gastrointestinal tract. The most commonly used method of administering protein/peptide compounds is parenteral delivery in liquid form. However, protein drugs administered by these routes have low bioavailability because they are rapidly eliminated from circulation through renal filtration and enzymatic degradation. Therefore, designing new drug delivery systems has become critical to the success of such active drug molecules, which can help:

Improve bioavailability.
Enhance patient compliance.
Increase targeting.
Reduce dosing frequency.
Prolong the duration of drug action in the body.
Reduce side effects.

Explore Our Proteins & Peptides Innovative Delivery System Delivery Development Services

Encapsulation of proteins/peptides into micro- or nano-carriers is a promising approach to enhance the stability of therapeutic peptides and proteins, which can protect drugs from the harsh environment in the body, deliver protein/peptide drugs to specific target sites, and release from particles by diffusion, swelling, erosion, or degradation.

At CD Formulation, our formulation scientists are adept at using a variety of innovative drug carriers, such as nanoparticles, polymer nanoparticles, liposomes, hydrogels, microemulsions, etc. to deliver your proteins and peptides. These drug carriers have different properties that can help enhance the solubility, stability, and bioavailability of your therapeutic proteins/peptides, thereby improving drug efficacy and reducing dosage.

Importantly, our formulation scientists can also customize specific drug carriers according to your needs to ensure optimal drug delivery and stability.

In addition to drug carrier selection, our team of formulation scientists focuses on continuous innovation and optimization of formulation technology to improve the stability and bioavailability of proteins and peptides. The best delivery effect is achieved by systematically optimizing different formulation parameters, including the ratio of drug and carrier, solvent selection, pH value, temperature, etc. Rigorous stability testing is performed to ensure that the formulation does not lose activity during long-term storage and use.

We offer the following innovative drug delivery system development services for your proteins and peptides:

General Workflow of Our Proteins & Peptides Innovative Delivery System Development

Fig. 1 Workflow for proteinsp/peptides nano delivery system development. Fig.1 Workflow for protein/peptide innovative delivery system development. (CD Formulation)

Characterization of therapeutic proteins and peptides, including solubility, primary and higher-order structures, amino acid sequences, post-translational modifications, and aggregation analysis.
Screening for the best drug delivery method based on the application route, including conventional oral administration, transdermal administration, injection, inhalation, etc.
Once the best delivery route for the target ingredient is determined, our team of experts will test different types of excipients to evaluate their effects on the stability of therapeutic proteins and peptides, thereby screening the best buffers and excipients to stabilize proteins and peptides.
On this basis, formulation research is carried out, involving screening or custom design of various innovative nanocarriers, with microneedles being given priority for transdermal delivery to improve drug stability and bioavailability.
Stability and drug release evaluation, which involve evaluating the drug release kinetics and stability of the target delivery system in different environments to determine its performance and reliability in a real in vivo environment.
Preclinical studies, including cytotoxicity studies, biocompatibility evaluation, pharmacodynamic evaluation, etc.

Why Choose Us for Proteins & Peptides Innovative Delivery System Delivery Development?

Decades of experience and achievements in the development of therapeutic protein and peptide drug formulations and drug delivery systems
Master the latest expertise in therapeutic protein and peptide formulations and drug delivery systems.
Support the development of a variety of therapeutic protein and peptide drug delivery systems, including but not limited to oral, transdermal, injection, inhaled, intranasal, targeted, etc.
The design and optimization of a variety of innovative delivery vehicles, including liposomes, microneedles, polymers, hydrogels, polysaccharides, etc., ensure the smooth implementation of various therapeutic protein and peptide drug delivery system projects.
Advanced technical means include nanotechnology, microfluidic, bioengineering, etc.
Flexible experimental design and customized solutions.

Publication

Published Data

Technology: Liposom Technology

Journal: J Pharm Sci.

IF: 3.5

Published: 2018

Results:

The authors developed a chitosan (CS)-coated cationic liposome for oral administration of insulin. The performance of CS-coated liposomes and uncoated liposomes was examined by in vitro, ex vivo, and in vivo studies in streptozotocin-induced diabetic mice. The results showed that the nanosize of CS-coated liposomes was 439.0±12.3 nm, the Zeta potential ( +60.5 ± 1.9 mV) was significantly reduced, and it had a high encapsulation efficiency. The tissue residence time of CS-coated liposomes was increased. The blood glucose of mice orally administered with CS-coated liposomes was significantly reduced and maintained for up to 8 hours. This indicates that CS-coated insulin-loaded cationic liposomes improve drug loading efficiency and are expected to prolong the hypoglycemic pharmacological effect.

CD Formulation masters the most advanced technology and industry knowledge in the development of therapeutic protein and peptide delivery systems and is committed to providing customers with high-quality, innovative, and reliable solutions to help them achieve their drug delivery goals. Please don't hesitate to contact us if you are interested in our services.

References

Chen G, Kang W, Li W, et al. Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies. Theranostics. 2022,12(3):1419-1439.
Nicze M, Borówka M, Dec A, et al. The Current and Promising Oral Delivery Methods for Protein- and Peptide-Based Drugs. International Journal of Molecular Sciences. 2024, 25(2):815.
Shalaby TI, El-Refaie WM. Bioadhesive Chitosan-Coated Cationic Nanoliposomes With Improved Insulin Encapsulation and Prolonged Oral Hypoglycemic Effect in Diabetic Mice. J Pharm Sci. 2018,107(8):2136-2143.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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