Oral Thin Film for Respiratory Disease Therapy Research

Respiratory system disease is a common disease, frequently occurring, with main lesions in the trachea, bronchus, lungs, chest and other parts. Commonly used treatment drugs include bronchodilators, corticosteroids and other medications. Oral thin film delivery system can deliver drugs directly to the lungs, so as to play a curative effect. CD Formulation specializes in providing cutting-edge oral thin film formulation research and development services for respiratory system drug delivery. Leveraging advanced oral thin film platforms, we deliver tailored solutions to meet the diverse needs of pharmaceutical companies and research institutions.

Application of Oral Thin Film in Respiratory Disease Therapy

Applications	Detailed Case
Case 1: Treatment of Asthma	Montelukast oral thin film is used to prevent wheezing, difficulty breathing, chest tightness, and coughing caused by asthma in adults and children 12 months of age and older.
Case 2: Treatment of COPD COPD cannot be completely cured using pharmacotherapy alone owing to biological barriers, low drug bioavailability and associated safety concerns, so there is an urgent need to explore new therapies.	Fig. 1 Sources of ROS and differences between a healthy lung and a lung with COPD. (You Xu, et al., 2020)
Case 3: Treatment of Respiratory Infection	An orodispersible film with the loading of the antibacterial agent cefixime trihydrate for infections of the respiratory tract is designed to cope with trouble in swallowing conventional oral dosage forms as well as to enhance water solubility and mask the bitter taste of the drug.

Oral Thin Film Preparation Technologies

Oral thin films can be accurately dosed, offering a precise way to administer medications, especially delivering the precise therapeutic dose for pediatrics. To achieve a personalized or tailored dosage of oral thin film, our team of experts has built a printing technology platform to print layer by layer by adding materials or excipients to achieve precise and flexible personalized drug delivery, including inkjet printing, 3D printing, etc.

Inkjet Printing

Inkjet printing is used for the fabrication of oral thin film which provides flexible dosing to meet different requirements of individuals. There are three main steps in using inkjet printing to manufacture oral thin films:

• Preparation of drug suspension as the ink
• Deposition of the ink onto the oral thin film in a defined pattern
• Drying

Due to the high precision and accuracy of printing technology, even tiny volumes of drugs could be dispensed onto film substrate allowing to deliver the precise therapeutic dose for pediatric.

Fig.2 Orodispersible film preparation. (Patrícia Batista, et al., 2023)

Custom Oral Thin Film Development Services

Our team of experts specializes in designing and developing innovative oral thin film formulations research services that can create different types of oral thin films.

Our team of experts is committed to designing and developing innovative oral thin film formulations for respiratory system applications. For inquiries about our R&D services, please contact us via phone or email, and our team will respond within three business days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.