Quick Release Oral Thin Film Development
Inquiry
Quick release oral thin film is a new drug delivery system that can rapidly disintegrate or dissolve on the tongue or in the mouth to ensure rapid absorption of the active pharmaceutical ingredients (APIs). CD Formulation has advanced quick release oral thin film delivery platform and technical expertise, whether you need to develop a new quick release oral thin film formula from scratch or need to optimize an existing formula, we can provide you with efficient and reliable services.
Why Develop Quick Release Oral Thin Film?
Quick release oral thin film is the first choice for rapid drug delivery, generally composed of APIs, film-forming agent, plasticizer, corrigent, flavor and pigment, etc., which can quickly dissolve and release drugs in the mouth. It is especially suitable for patients with fever, pain relief, allergy, motion sickness, cough, sleep disorders and central nervous system. Compared with conventional dosage forms, quick release oral thin film has many advantages, for drugs with local action, it can directly act on the lesion and improve bioavailability, for drugs with systemic action, the APIs can be directly absorbed through the oral mucosa, avoiding the first pass effect. It is convenient to take medicine, needless to be taken with waterno dangerous for blocking the throat, and suitable for children and elderly patients, improving the compliance of patients.
Our Quick Release Oral Thin Film Development Services
As a global leader in oral thin film development, CD Formulation has extensive experience in the development of quick-release oral thin film formulation. Our unparalleled team of experts is committed to helping you solve any difficulties and challenges that may arise in the development of quick-release oral thin film formulations.
Formulation Design
In the formulation design process, our team of experts selects the corresponding APIs according to the requirements of customers, and selects the appropriate film forming polymers, plasticizers, saliva irritants, sweeteners, flavors, preservatives, masking agents, and colors according to the properties of the active ingredients. Importantly, our expertise can develop flavor masking solutions for bitter APIs.
Preparation Method Screening
The preparation methods of quick release oral thin film have solvent casting, extrusion, roll-to-roll methods, etc. Currently, the commonly used preparation methods are solvent casting and roll-to-roll method. Our team of experts selects the most suitable preparation method according to the properties of the customer's APIs and other ingredients and develops high-quality quick release oral thin films.
Quality Control
Our experienced technicians carry out comprehensive quality control, including physicochemical characterization, development and validation of analytical methods, stability testing, etc.
Manufacture
We have very rich experience in pilot transfer of quick release oral thin film, and we also have strong manufacturing capabilities.
Fig.1 Process of Quick Release Oral Thin Film Development. (CD Formulation)
Our Technologies for Quick Release Oral Thin Film Development
| Technologies & Platform |
Specifics Contents |
| Excipient Screening Platform |
The formulation of oral thin films involves complex applications of aesthetics and drug properties, such as masking taste, rapid dissolution, physical appearance, taste, etc., which are achieved by excipient composition and certain technical means, we have a special excipient screening platform, including screening appropriate film-forming polymers, plasticizers, saliva irritants, sweeteners, flavors, preservatives, masking agents, and colors according to the properties of the active ingredients. |
| Preparation Process Screening Technology Platform |
The preparation methods of quick release oral thin film have solvent casting, extrusion, roll-to-roll methods. We are familiar with the advantages and disadvantages of various preparation technologies, we will combine the properties of raw materials and APIs, customer needs and budget, screen the most suitable preparation method to develop high quality quick release oral thin films. |
| Analysis and Characterization Platform |
We can offer multiple analysis methods to confirm the quality of quick release oral thin film, including surface pH, thickness, swelling index, disintegration time, mechanical properties, tensile strength, etc. Our analytical laboratory center is equipped with a variety of advanced equipment. |
Our Advantages in Quick Release Oral Thin Film Development Services
- We have a strong ability to mask the bad taste of APIs and maximize patient compliance.
- We can support you in every step of the development of quick-release oral thin film, covering the screening of film-forming agents, disintegrants, and taste-masking agents, as well as improving the dissolution and stability of some drug molecules with special properties.
- Our team of experts can adjust the formulation and the proportions of ingredients in the formulation as well as process parameters according to your specific requirements to ensure the development quality of quick-release oral thin film.
- We have a variety of preparation techniques to choose from.
- We adhere to the highest quality standards to ensure that the quick release oral thin film developed complies with all laws and regulations.
- We provide end-to-end services, from pre-formulation research to commercial production, to ensure customers can bring their products to market as quickly as possible.
Published Data
Technology: Electrospinning technology
Journal: International Journal of Biological Macromolecules
IF: 8.2
Published: 2019
Results: In this study, the fast-dissolving oral films were successfully fabricated from chitosan and pullulan with different proportions in the form of self-standing nanofiber films without using any inedible polymeric matrix by electrospinning technique. SEM results suggested that the diameter of nanofibers increased firstly and then decreased with the increase of chitosan content in solutions. FTIR and XRD analysis proved the interaction and miscibility between two polymer chains.
Fig.2 Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers. (Ze-yu Qin, et al., 2019)
CD Formulation is at the forefront of the development of innovative drug delivery systems, providing customized solutions for quick release oral thin film development. Our advanced technology and equipment make us a reliable partner in the development of quick release oral thin film. If you have a requirement about our quick release oral thin film development services, please contact us by phone or email, our colleagues will reply to you within three working days.
References
- Thonte S.S., Bachipale R.R, et al. Formulation and Evaluation of Oral Fast Dissolving Film of Glibenclamide. Human Journals. 2017, Vol. 10 (4): 15-39.
- Atri, Ava, Formulation and characterization of oral dissolving films with ascorbic acid (2022). Selected Full-Text Master Theses. 2022. 8.
- K.VIJAYA SRI1,P.ROHINI1 AND G, et al. MONTELUKAST SODIUM ORAL THIN FILMS: FORMULATION AND INVITRO EVALUATION. Asian J Pharm Clin Res, 2012, Vol 5. Suppl 4, 266-270.
- Sana Javed, Amjad Hussain, et al. Development of Optimized Sumatriptan - Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization. AAPS PharmSciTech. 2022, Vol. 23.
- Ze-yu Qin, Xi-Wen Jia, et al. Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers. International Journal of Biological Macromolecules. 2019, Vol (137):224-231.
How It Works
STEP 2
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STEP 3
Execute the project with real-time communication, and deliver the final report promptly.
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