Oral Thin Film for Pain Relief Research
Inquiry
Pain relief medicines or analgesia are in high demand for many pain disorders needed for systemic delivery, for example, back pain, headaches or migraine, joint pain, and even cancer pain. As the fast onset of action of drugs is highly required for treating pain disorders, the combination of analgesia with oral thin films seems to be prominent. CD Formulation has conducted extensive research and development to ensure the safety and efficacy of the oral thin film technology, and we can load active ingredients for pain treatment into oral thin film drug delivery systems, helping customers develop high-quality oral thin drugs for pain relief.
Application of Oral Thin Film in Pain Relief
Oral thin films can deliver various analgesics, including:
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Nonsteroidal anti-inflammatory drugs (NSAIDs) are primarily utilized as pain relief medicines and oral thin films can deliver NSAIDs, which are commonly used to relieve mild to moderate pain and reduce inflammation.
- Opioids: Opioid analgesics may be needed for some pains that fail to be relieved by NSAIDs, such as buprenorphine, fentanyl, or oxycodone, for managing moderate to severe pain.
Fig.1 Buprenorphine buccal film. (Martin Hale, et al., 2020)
- Local Anesthetics: Some local anesthetics can also load into oral thin film delivery systems, which can provide temporary pain relief for conditions like toothaches or mouth sores.
- Analgesics: Oral thin films can contain various analgesic medications, like acetaminophen, to alleviate pain and reduce fever.
Cases of Oral Thin Film for Pain Relief
At present, many research cases are using oral thin film to deliver API for pain relief, such as:
| Commercial Name |
Active Ingredients |
Usage |
| Chloraseptic® Sore Throat Relief Strips |
Benzocaine |
Sore throat |
| Orajel® Toothache Strips |
Benzocaine/menthol |
Relieving pain in the mouth and gums |
| Zolmitriptan RapidFilm™ |
Zolmitriptan |
Migraine |
| Onsolis®/Breakyl® |
Fentanyl |
Breakthrough pain in patients with cancer |
| BELBUCA® |
Buprenorphine |
Relieving of chronic pain |
Our Services for Oral Thin Film in Pain Relief Research
As an oral thin film formulation development company, we provide solutions to help customers develop oral thin films to relieve pain, including customized formulation development, taste masking, scale-up and manufacturing, quality control, etc.
Customized Formulation Development
According to the needs of customers and the properties of active ingredients, we can screen preparation methods, excipients, flavoring agent etc.
Taste masking
Many active ingredients used to relieve pain have a specific bitter taste, and we have professional masking technology that can effectively mask the bitter taste of the active ingredients.
Scale-up and Manufacturing
We provide a scale-up production plant that meets international standards to help customers produce oral thin films that meet global standards.
Quality Control
Our experienced technicians carry out comprehensive quality control, including physicochemical characterization, development and validation of analytical methods, stability testing, batch release testing, etc.
Why Choose CD Formulation?
- Custom Formulation Services: Tailored to your project's needs.
- Rapid Response: Meeting your timeline requirements for formulation development and characterization.
- Comprehensive Support: From initial design to final evaluation, we provide complete R&D support for your project.
Published Data
Technology: Etoricoxib Mouth Dissolving Film for Pain Management
Journal: Advance in pharmaceutics
IF: 2.0
Published: 2015
Results: Etoricoxib is a potent, orally active, and highly selective COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic activities. The present research was undertaken to develop mouth-dissolving films of etoricoxib to have a rapid onset of action. The analgesic activity of etoricoxib MDF was studied using a tail-flick test in Wistar rats. The results show that etoricoxib MDF and commercially available immediate-release tablets showed significant activity at 20 min when compared to the control (P < 0.01), in the dissolved state leading to immediate absorption followed by fast analgesia greater than/comparable to that of IR tablets of etoricoxib better management of pain will be possible with the developed etoricoxib MDF.
Table. 1 Evaluation of analgesic activity by tail-flick test (reaction time). (K. Senthilkumar, et al., 2015)
CD Formulation specializes in developing oral thin films utilizing our core technologies. If you require our oral thin film services for pain relief research, please contact us by phone or email, and our colleagues will get back to you within three working days.
References
- K. Senthilkumar, C. Vijaya. Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management. Advance in pharmaceutics. 2015.
- Yu Tian, Jiangtao Lin, et al. Recent progress in orodispersible films-mediated therapeutic applications: A review. MedComm–Biomaterials and Applications. 2022.
- Martin Hale, Joseph Gimbel, et al. Buprenorphine Buccal Film for Chronic Pain Management. Pain Management. 2020, Vol (10):213:223.
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