Biologics are a pivotal part of modern medical treatments and are rapidly advancing as a therapeutic class due to their clinical success. With the growing importance of biologics in the pharmaceutical sector, there is significant interest in developing non-invasive delivery systems. Oral thin film delivery is particularly promising for biologics, allowing enhanced systemic absorption without invasive methods. At CD Formulation, our advanced oral thin film biologics delivery platform enables efficient development of oral thin films tailored to specific biologic compounds.

Fig.1 Development and characterization of chitosan films impregnated with insulin. (Concetta Giovino, et al., 2012)

Advantages of Oral Thin Film Biologics Delivery

Biologics are initially developed as injectables due to their limited stability through the gastrointestinal tract and solubility issues. The buccal route presents several advantages with the emergence of oral mucosal drug delivery routes. As an alternative site for biologics absorption, oral thin film biologics can bypass enzymatic degradation and the first-pass effect and improve bioavailability.

Our Oral Thin Film Biologics Delivery Technologies

At CD Formulation, we provide comprehensive solutions for oral thin film biologics. With years of experience, we specialize in producing biologic-loaded thin films that address challenges such as low bioavailability and thermal sensitivity. Our oral thin film biologics delivery technologies include:

Oral Thin Film Vaccine Delivery Technology

Oral thin film vaccine delivery technology shows great promise as a convenient, non-invasive, and potentially effective method for delivering vaccines that rapidly dissolve in the mouth, allowing for quick and easy administration without the need for needles or injections.

Oral Thin Film Peptide Delivery Technology

Oral thin film peptide delivery technology can improve bioavailability and rapid onset of action for peptides, as the oral mucosa can provide direct access to the bloodstream, bypassing the digestive system and potential degradation of the drug in the stomach and intestines. This delivery technology can enhance the therapeutic efficacy of peptide-based treatments.

Custom Oral Thin Film Biologics Development Services

CD Formulation has established an advanced oral thin film biologics development platform that can provide one-stop oral thin film biologics customization services, mainly including formulation development, biocompatibility study, drug loading and release, bioavailability study, stability and shelf-life study, etc.

Fig.2 Our workflow for Oral Thin Film Biologics Development. (CD Formulation)

• Formulation Development: Formulation development includes the selection of appropriate excipients, stabilizers and delivery enhancers to protect organisms from degradation and enhance their absorption, as well as evaluating preparation processes and methods.
• Biocompatibility Study: The materials used in the oral thin film must be biocompatible to ensure the safe and effective delivery of biological drugs. We will pay close attention to the compatibility of the thin film components with the biological drug.
• Drug Loading and Release: The thin film must allow for controlled and efficient release of the biological drug to optimize its absorption and therapeutic effect. We incorporate nanoparticles and specialized delivery systems to achieve targeted release profiles.
• Bioavailability Study: To improve the bioavailability of the biologic drug, we incorporate absorption enhancers or permeation enhancers in the thin film formulation.
• Stability and Shelf-Life Study: Following the ICH stability testing guidelines, our analytical laboratory utilizes various techniques to develop and validate stability indication methods to identify and quantify degradation products.

Why Choose CD Formulation?

• We have accumulated rich experience and practical skills in developing, preparing and characterizing oral thin films.
• Our core team has rich expertise in researching oral thin film biologics drug delivery system strategies, especially in oral thin film vaccine and peptide delivery.
• We are good at designing and customizing biologics drug delivery systems for oral thin film, ensuring that the quality of biologics drug delivery systems meets customers' specific requirements.

Published Data

CD Formulation has always been at the forefront of oral thin film formulation development. With the support of our advanced oral thin film platform, we provide customized formulation development services for oral thin film biologics. If you require our oral thin film biologics delivery technology services, please contact us by phone or email, and our colleagues will get back to you within three working days.