Peptides are short polymers composed of about 20 ~ 50 amino acids, and protein is a macromolecular and high molecular weight polypeptide composed of more than 50 long-chain amino acids arranged into linear chains by peptide bonds. Therapeutic proteins and peptides have unique and unparalleled pharmacological properties with better therapeutic indices. However, proteins also have the limitation of low bioavailability and are often repeatedly administered through invasive routes, with the advent of oral thin film drug delivery technology, which can significantly improve the biological performance of proteins and peptides. CD Formulation has established an oral thin film protein/peptide technology platform to facilitate the development and investigation of protein/peptide utilizing oral thin film delivery systems, promoting the development of protein/peptide drugs.

Fig.1 Oral films for oral delivery of proteins/peptides. (Pedro M. Castro, et al., 2015)

Advantages of Oral Thin Film Protein/Peptide Delivery Technology

• Oral thin film protein/peptide delivery systems can increase the bioavailability of products.
• Cheaper production costs and extended life of therapeutic proteins/peptides in oral thin film form lead to easy transport and storage.
• Therapeutic proteins/peptides in oral thin film forms are age-appropriate dosage forms that increase compliance in paediatrics and the elderly.

Fig.2 Therapeutic proteins and peptides in orally disintegrating dosage forms. (Shazia Bashir, et al., 2023)

Our Oral Thin Film Protein/Peptide Delivery Technologies

CD Formulation is a leader in oral thin film and protein/peptide drug development and manufacturing. Over the past few years, we have been working on applying oral thin film technology to deliver protein/peptide drugs. We have established an advanced oral thin film protein/peptide drug delivery platform to help our customers develop and characterize proteins/peptide drugs that meet their needs.

Manufacturing Strategies of Oral Thin Film Protein/Peptide

Oral thin film protein/peptide drugs can comprise one or multiple layers that contain APIs and suitable excipients, such as adhesives to optimize function, and its production methods mainly include solvent casting method, 3D printing method, electrospinning, etc.

Fig.3 Oral Protein and Peptide Manufacturing Technologies. (Shazia Bashir, et al., 2023)

Strategies for Enhancing the Stability of Protein/Peptide in Oral Thin Film

The structural stability of proteins or peptides is a major factor in biological activity; therefore, physical and chemical stability must be guaranteed. Our team found that adding excipients such as polymers and sugars used to fabricate oral thin films can confer stability to protein/peptide.

Another innovative delivery platform we are developing to improve the stability of protein/peptide in oral thin film systems is nano- and microparticle technology, which can enhance the permeability of protein/peptide in mucosal epithelial cells, prevent enzymatic degradation and maintain the stability of protein/peptide during processing, manufacturing, and storage.

Explore Our Oral Thin Film Manufacturing Technologies

We provide specialized manufacturing services for oral thin film protein and peptide delivery. This innovative drug delivery system is designed to provide an efficient and convenient method for delivering proteins and peptides through oral administration, overcoming traditional challenges associated with the oral delivery of biologics.

Why Choose CD Formulation?

• We have established an oral thin film protein/peptide technology platform and can design and prepare high-quality protein/peptide drugs to meet customers' needs.
• We have advanced instruments and equipment and can also provide you with the preparation and characterization of oral thin film protein/peptide drugs that meet your quality requirements.
• We offer customizable formulations to meet the specific needs of different proteins/peptides, ensuring optimal delivery and efficacy for each therapeutic compound.

Published Data

CD Formulation as a world-class oral thin film R&D company, is committed to exploring and constructing innovative oral thin film protein/peptide technology platforms. If you require our oral thin film protein/peptide delivery technology services, please contact us by phone or email, and our colleagues will get back to you within three working days.