Buccal mucosa has a large surface area and immunological competence, making it an ideal site for the administration of vaccines. The oral thin film can deliver vaccines either in pure or particulate form to these cells for buccal delivery. Unlike traditional vaccination approaches, oral thin film vaccine delivery technology is an emerging, exciting concept that can be used in the field of pharmaceuticals for vaccine design and formulation development. CD Formulation has established an oral thin film vaccine technology platform to facilitate the development and investigation of vaccines utilizing oral thin film delivery systems, assisting researchers in leveraging this technology for vaccine drug delivery applications.

Fig.1 Design buccal film with different functions for unidirectional release of antigen. (Shery Jacob, et al., 2021)

Advantages of Oral Thin Film Vaccines

Oral thin films are novel oral vaccine carriers that could improve the mass immunization process to reach the herd immunity threshold. There are many advantages:

Easy to Store: Compared with traditional liquid vaccines, oral thin film vaccines are more accessible to store and transport, reducing refrigeration and special handling requirements.

Needle-free Delivery: The traditional way vaccines are administered is usually intramuscular and subcutaneous. Compared with conventional injectable forms, oral thin film vaccines have unique advantages, such as improving patient compliance, eliminating the risk of needle stick injuries and the need for proper disposal of medical waste.

Improved Immune Response: Oral thin film can produce strong mucosal immunity and better protection against respiratory and other transmitted diseases.

Fig.2 Zika MPs loaded in oral thin films in the buccal mucosa. (Sarthak Shah, et al., 2024)

Our Oral Thin Film Vaccine Delivery Technologies

CD Formulation is innovative and constantly exploring and has established an oral thin film drug delivery platform for the development, characterization and production of oral thin film vaccines.

Oral Thin Film Vaccine Preparation Technologies

The key to the oral thin film vaccine delivery system is the preparation of vaccine particles and oral thin film suspension and selecting a suitable method to prepare the oral thin vaccine.

• Microparticle Vaccine Preparation
• Preparation of Oral Thin Film Suspension
• Preparation of Oral Thin Film Vaccines: The preparation method includes solvent casting methods, 3D printing methods, etc.

Characterization

• Particle Size Analysis & Zeta Potential
• Morphological Characterization of Oral thin Film Vaccines
• Physiochemical Assessment of Oral thin Film Vaccines

Evaluation of Oral Thin Film Vaccines

• Immunostimulatory Potential of Oral Thin Film Vaccine
• Induce Autophagosomes Ability of Oral Thin Film Vaccine
• Cytotoxicity of Oral Thin Film Vaccine

In Vivo Studies for Vaccine Development

CD Formulation also provides in vivo studies, including the design of animal models, dosing regimens, and flow cytometry analysis of immune response organs such as the spleen and lymph nodes.

Fig.3 The production method of the orally disintegrating film (ODF) loaded with the vaccine. (Rikhav P. Gala, et al., 2017)

Why Choose CD Formulation?

• We have built two major technical platforms for preparing and characterizing oral thin film vaccines, helping researchers focus on the research and development of oral thin film vaccines.
• Based on our oral thin film and vaccine preparation technology platforms, we can choose appropriate preparation methods to provide customers with customized oral thin film vaccine services based on clients' needs.
• Our team has rich experience in exploring and constructing oral thin film vaccines and can provide a quick response to customers' requirements for oral thin film vaccine formulation development and characterization immediately.

Published Data

CD Formulation provides global researchers with oral thin film vaccine technology services depending on our advanced oral thin film and vaccine technology platforms. If you require our oral thin film vaccine delivery technology services, please contact us by phone or email, and our colleagues will get to you within three working days.