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Particle Size Analysis for Nucleic Acid Drugs

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CD Formulation provides specialized particle size analysis services for nucleic acid drugs, offering precise testing techniques essential for research and development. Our services cater to various forms of nucleic acid drugs, ensuring highly accurate and reproducible particle size measurements. Utilizing advanced instrumentation, we can detect particle size distribution characteristics in samples, aiding researchers and developers in optimizing product properties and quality.

About Particle Size Analysis

The aim of particle size testing for nucleic acid drugs is to analyze and control the physical properties of the drugs, which is crucial for manufacturing processes and product stability. By understanding the particle size distribution data, one can optimize the solubility, absorption rate, and drug delivery system design, making production processes more precise and efficient. Moreover, a thorough understanding of particle size characteristics helps ensure consistency between batches and quality control, thereby enhancing the reliability and efficiency of research and development efforts.

Fig.1 Analysis of particle sizes in nucleic acid drugs. Fig.1 Nucleic acid drug particle size analysis. (CD Formulation)

Particle Size Analysis Methods

Methods	Descriptions
Microscopy Method	The microscopy method involves examining the sample under a microscope to determine particle size. Only a small amount of sample is measured, thus it must be representative and well-dispersed. The particle image is projected onto a screen with a ruler or geometric shapes, and size is determined by comparison.
Coulter Counter Method	This technique involves dispersing the powder in an electrolyte solution, and as particles pass through a small orifice under a pressure difference, they generate a voltage pulse proportional to their volume or diameter.
Sedimentation Method	Sedimentation measures particle size distribution based on varying sedimentation velocities of particles in a liquid. The sample is mixed into a suspension, and particles settle under gravity or centrifugal force.
DLS Method	DLS is used for measuring size distribution of nanomaterials by analyzing their Brownian motion in liquid, inferring particle size from movement detected by scattering.

Explore Our Particle Size Analysis for Nucleic Acid Drugs

Lipid Nanoparticle Size Analysis

The size analysis of lipid nanoparticles in nucleic acid drugs ensures physical stability and uniformity, optimizing their performance during research and development. Precise size measurement allows scientists to adjust and enhance formulations, improving drug delivery efficiency and bioavailability. This aids stability studies and reveals nanoparticle behavior under various environmental conditions, providing valuable insights for further research.

Nucleic Acid Drug Particle Size Distribution Analysis

Particle size distribution testing is crucial for analyzing internal structural characteristics of nucleic acid drugs by measuring the percentage content of particles across various sizes. This analysis uses advanced instruments and specific methods to present data in interval or cumulative distributions. Interval distribution, or differential distribution, displays the percentage of particles within size ranges, revealing subtle differences. Cumulative distribution indicates the percentage of particles smaller or larger than a specific size, providing a holistic view of uniformity and stability, essential for optimizing production processes and ensuring product consistency.

Our Workflow of Particle Size Analysis for Nucleic Acid Drugs

Fig.2 Diagram of the process for analyzing nucleic acid particle sizes. Fig.2 Flow chart of nucleic acid particle size analysis. (CD Formulation)

Sample Preparation

Collect and process nucleic acid drug samples to ensure suitability for particle size analysis, removing impurities that could affect results.

Instrument Selection

Choose the appropriate particle size analysis instrument based on the properties of the nucleic acid drugs and analytical needs, such as laser diffraction or electron microscopy.

Measurement Implementation

Conduct particle size measurement with selected instruments, recording distribution and proportions of particles across different sizes.

Data Analysis

Organize and analyze measurement data, generating interval and cumulative distribution charts to accurately reflect sample particle size characteristics.

Result Reporting

Provide a detailed analysis report, including measurement methods, particle size distribution data, and conclusions, aiding researchers in product development.

Our Technology Platforms

Items	Descriptions
DLS Platform	DLS is a key technique for analyzing particle size distribution at the submicron level, inferring size by detecting particle movement in liquid, suitable for nanoparticles.
SEM Platform	SEM examines and analyzes surface morphology to provide high-resolution images of particle size, shape, and structure, especially useful for solid nucleic acid drugs.

Our Advantages of Particle Size Analysis for Nucleic Acid Drugs

Utilizing advanced instrumentation, we offer high-precision particle size measurements of nucleic acid drugs, ensuring data accuracy and reliability.
Our services aim to reduce analysis timeframes, delivering results swiftly to enhance R&D project efficiency.
We conduct effective particle size analysis on both synthetic nucleic acids and natural extracts, meeting diverse research needs.
Beyond basic testing results, we provide comprehensive data analysis and reporting to help understand the impact of particle size characteristics on applications.

Publication Data

Technology: Particle size analysis of nucleic acids by DLS technology

Journal: Human vaccines & immunotherapeutics

IF: 4.1

Published: 2013

Results:

The author created a new RNA vaccine with two key features: it uses modified mRNA to boost protein expression by 4-5 orders of magnitude using natural nucleotides (A, G, C, and U) without changing the amino acid sequence. Additionally, these nucleotides form a complex with protamine, activating the immune system via TLR7, giving the vaccine self-adjuvant activity. After vaccination, pre-germinal and germinal center B cells are detectable.

Fig.3 Examination of particle sizes in RNA vaccines. Fig.3 Size analysis of RNA vaccines. (Kallen K J, et al., 2013)

If you require nucleic acid drug particle size analysis or more information, please contact us. Our team is ready to provide expert solutions to support your research and development efforts.

References

Kallen K J, Heidenreich R, Schnee M, et al. A novel, disruptive vaccination technology: self-adjuvanted RNActive® vaccines. HUM VACC IMMUNOTHER. 2013, 9(10): 2263-2276.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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