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Scanning Electron Microscope (SEM) Platform for Nucleic Acid Drugs

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CD Formulation is a biopharmaceutical and drug discovery company that offers a variety of analytical services to support the development of nucleic acid drugs. Scanning Electron Microscopy (SEM) plays a crucial role in nucleic acid drug discovery and development by serving as a powerful characterization tool that delivers high-resolution information on the surface morphology and structure of samples.

Scanning Electron Microscopy (SEM) Platform for Nucleic Acid Drugs

Scanning Electron Microscopy (SEM) platforms play a crucial role in the analysis of nucleic acid drugs by providing high-resolution imaging of sample surfaces. This technology enables researchers to gain insights into the microstructure and morphology of these drugs. Nucleic acid drugs often encounter challenges related to preparation and stability due to their complex physical properties. SEM technology allows for the effective observation of their aggregation state, particle size distribution, and shape characteristics, thereby providing essential characterization data for drug development to ensure safety and efficacy.

Fig.1 SEM technology platform for nucleic acid drugs Fig.1 Advantages of scanning electron microscopy (SEM) platform. (CD Formulation)

Types of Scanning Electron Microscopy (SEM) Platform

CD Formulation provides a diverse selection of electron microscopy equipment, including environmental SEM and high-resolution scanning electron microscopes known for their exceptional contrast. SEM platforms offer significant flexibility and a wide array of functionalities. Regardless of the size and weight of the sample, SEM platforms facilitate the acquisition of outstanding images and reliable analysis results.

Platforms	Descriptions
Environmental SEM Platform	Tungsten filament SEM with unique environmental capabilities. Simple and efficient sample loading capabilities, along with seamless navigation through multiple samples.
Ultra-high resolution field emission SEM Platform	Electron gun with monochromator for easy sub-nanometer resolution at both high and low voltages. Electron beam landing energy can be as low as 20 eV, making it highly suitable for the characterization of electron beam-sensitive materials. The piezo ceramic sample stage is standard for exceptional accuracy and stability.
Environmental Field Emission SEM Platform	High-resolution field emission scanning electron microscope with unique environmental capabilities. Enables scanning transmission (STEM) observation of wet samples.
Versatile Real-Time Spectroscopic SEM Platform	True real-time quantitative elemental analysis. Low-vacuum mode offers the same resolving power as high-vacuum mode, allowing for the straightforward analysis of charged samples. Standard secondary electron, motorized telescopic backscattered electron, and energy spectrum probes.
Multi-functional high-resolution field emission SEM Platform	Superior SEM performance for spatial resolution applications at the nanometer and sub-nanometer scale. A nanosecond T1 scintillator detector for producing excellent backscattered electron contrast images. Excellent spatial resolution at extended working distances (10 mm).

Specifications of Scanning Electron Microscope Technology

Signals detected: secondary and backscattered electrons, X-rays, light (cathodoluminescence) and electron beam induced current (EBIC)
Elements detected: BU (EDS mode)
Detection limits: 0.1-1 at%
EDS chemical depth resolution: 0.1-3 µm
Lateral Resolution/Probe Size: 10-30 Å

Highlights of SEM Platform for Nucleic Acid Drugs

SEM has a very high resolution, enabling the observation of surface structures and morphologies of samples at the nanometer scale.
Using SEM in conjunction with energy-dispersive X-ray spectroscopy (EDX), the chemical composition of the sample can be analyzed.
SEM can provide three-dimensional morphological information about a sample, which aids in studying its shape, size, distribution, and other characteristics.
SEM can operate at high accelerating voltages and possesses the ability to penetrate samples, allowing for the observation of their internal structures.
SEM performs high-resolution imaging and analysis while preserving the integrity of the sample, as it does not destroy it during the process.

Our Analytical Characterization Services

CD Formulation's SEM platform offers robust technical support for nucleic acid drug discovery and development. By conducting morphological analyses and stability studies, our platform can significantly enhance the efficiency and success rate of drug development, ensuring the competitiveness and safety of drugs in the market.

Morphological Analysis for Nucleic Acid Drugs

Our SEM platform facilitates comprehensive morphological analysis of nucleic acid drugs. Scanning electron microscopy offers high-resolution images that reveal the shape, size distribution, and surface structure of drug particles.

Stability Analysis for Nucleic Acid Drugs

The stability of a drug can be evaluated by observing morphological changes under various environmental conditions. SEM can detect subtle changes, which can be used to predict long-term stability of a drug.

Publication Data

Technology: SEM platform for analyzing extracellular vesicles (EVs)

Journal: Biomedicines

IF: 4.2

Published: 2021

Results:

Extracellular vesicles (EVs) are nanomembrane structures secreted by almost all cells and present in biological fluids. A prerequisite for the use of EVs is their detailed characterization, including visualization mainly by atomic force microscopy (AFM) and electron microscopy (EM). The authors summarize the protocols for EV preparation for AFM and EM and point out the main challenges for EV imaging, including the imaging of EVs in their natural environments as components of biofluids and in saline after EV isolation.

Fig.2 SEM platform for analyzing extracellular vesicles (EVs) Fig.2 Schematic representation of scanning electron microscope. (Malenica M, et al., 2021)

CD Formulation offers a SEM technology platform that not only delivers more accurate data for your research but also provides essential support for successful drug development. Contact us today for assistance in obtaining more information about our SEM platform analysis services.

References

Malenica M, Vukomanović M, Kurtjak M, et al. Perspectives of microscopy methods for morphology characterisation of extracellular vesicles from human biofluids. Biomedicines. 2021, 9(6): 603.

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STEP 2

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STEP 3

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