Nucleic Acid Drug Co-Delivery R&D Solutions

Through chemical modification and various methods, different nucleic acid drugs can be combined to create a composite drug for co-delivery. This approach can enhance therapeutic efficacy while minimizing the toxic side effects associated with the drugs. CD Formulation is dedicated to delivering advanced co-delivery solutions for nucleic acid drugs to the scientific research and pharmaceutical sectors.

Fig.1 Nucleic Acid Drug Co-Delivery. (CD Formulation)

Methods of Nucleic Acid Drug Co-Delivery

Nucleic Acid Drug Co-Delivery Solutions

Carrier Design and Optimization

The key to carrier design and optimization solutions lies in enhancing biocompatibility, stability, and targeting. Through chemical modification and surface functionalization, carriers can be improved for cell membrane penetration, reduced in particle size to enhance in vivo circulation time, and increased in surface ligands for specific cell or tissue recognition and targeted delivery. Additionally, these modifications can achieve synergistic therapeutic effects by loading multiple functional nucleic acid drugs.

Nucleic Acid Drug Modification Solutions

Co-delivery of nucleic acid drugs involves chemical modifications to enhance their stability, bioavailability, and intracellular transport efficiency. During the design process, protective groups can be utilized to shield the nucleic acid drug from degradation, while modifications such as PEGylation and lipid incorporation can be introduced to improve blood circulation time and facilitate cell membrane penetration.

Delivery Route Development

The development of delivery routes scientifically designs and optimizes the administration methods for nucleic acid drugs (e.g., intravenous injection, local injection, inhalation, etc.). This process is combined with the use of precise delivery systems to ensure that nucleic acid drugs can efficiently enter target cells or tissues and exert their effects.

Our Capabilities of Nucleic Acid Drug Co-Delivery Solutions

Nucleic Acid Drug Delivery Carrier Development

• Lipid-based Nanoparticle Development
• Inorganic Nanoparticle Development
• Polymer-based Nanoparticle Development
• Protein and Peptide-based Carriers Development
• Extracellular Vesicles (EVs) Development
• Spherical Nucleic Acid (SNA) Development
• Viral Vector Development

Nucleic Acid Drugs Delivery System Design

• Controlled Release Drug Delivery System Design
• Targeted Drug Delivery System Design
• Modification Services for Drug Delivery System

Dosage Form Development

• Oral Nucleic Acid Formulation Development
• Injectable Nucleic Acid Formulation Development
• Ophthalmic Nucleic Acid Formulation Development
• Nasal Nucleic Acid Formulation Development
• Transdermal Nucleic Acid Formulation Development

Highlights of Nucleic Acid Drug Co-Delivery Solutions

• The co-delivery system can simultaneously deliver multiple nucleic acid drugs (e.g., siRNA, miRNA, mRNA, etc.), achieving multi-targeted therapeutic effects and thereby enhancing treatment effectiveness.
• The protection of co-delivery carriers can enhance the stability of nucleic acid drugs in vivo, reduce their degradation, and improve the bioavailability of these drugs.
• Since co-delivery systems enhance the efficiency of drug delivery, it is often possible to lower the drug dosage, thereby minimizing the associated side effects.
• By co-delivering various types of nucleic acid drugs, synergistic therapeutic effects can be achieved, including the simultaneous inhibition of tumor growth and enhancement of the immune response, thereby accelerating disease improvement.

Publication Data

CD Formulation's nucleic acid drug co-delivery solutions ensure the stable and efficient delivery of nucleic acid drugs in vivo. By utilizing advanced carrier technology, we significantly enhance drug bioavailability and therapeutic efficacy. Contact us for a customized solution.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.