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Morphological Analysis for Nucleic Acid Drugs

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CD Formulation offers advanced microstructural analysis of nucleic acids, utilizing state-of-the-art technology and high-precision equipment for thorough and accurate assessments.

Explore Our Morphological Analysis for Nucleic Acid Drugs

In the morphological analysis of nucleic acid formulations, our platform is widely used to study the morphology and structural characteristics of nucleic acid drug particles. By placing drug formulation samples under an electron microscope and using a precisely focused electron beam for observation, detailed morphological information of nanoparticles can be obtained. During analysis, parameters such as particle size, shape, and surface characteristics are thoroughly investigated, revealing the structural characteristics of nucleic acid drugs. By calculating various shape parameters such as equivalent diameter, aspect ratio, and roundness, distribution maps can be generated to aid in understanding and optimizing the design and application of nucleic acid drug carriers, providing important structural evidence for improving drug delivery efficiency.

Morphological Analysis of Different Types of Nucleic Acid Formulations

Items	Descriptions
Lipid Nanoparticles	These tiny, spherical particles made of lipids enclose active materials. Their size and shape are examined using DLS and TEM to understand their distribution and surface features.
Liposomes	Comprising one or more layers of phospholipids, these spherical vesicles hold an internal aqueous environment. Techniques like Cryo-EM and SAXS help evaluate their structural layers and sizes.
Exosomes	With diameters of 30 to 150 nm, these cell-derived vesicles are formed under particular conditions. NTA and TEM tools measure their concentration, morphology, and dimensions.
Virus-Like Particles (VLPs)	These resemble viruses in shape but lack genetic content and are used in vaccines. EM and DLS analyze their size and structural uniformity.

Our Workflow of Morphological Analysis for Nucleic Acid Drugs

Fig.1 Visual process outline for analyzing the morphology of nucleic acid drugs. Fig.1 Flow chart of nucleic acid drug morphological analysis. (CD Formulation)

Sample Preparation

High-purity nucleic acid drug samples are obtained through appropriate separation and purification techniques to ensure the accuracy of morphological analysis.

Microscopic Observation

Optical or electron microscopes are used to observe and record the preliminary morphology of nucleic acid drugs, providing overall morphological characteristics and particle distribution information.

Particle Size Distribution Analysis

Techniques such as DLS are utilized to determine the particle size distribution of nucleic acid drugs to assess their uniformity and stability.

Surface Charge Measurement

Electrophoretic light scattering methods measure the Zeta potential of nucleic acid drug particles, aiding in understanding their surface charge and dispersibility.

Morphological Characterization Techniques

We utilize SEM for in-depth analysis of the surface features and intricate microstructures of nucleic acid therapies, delivering high-resolution images.

Our Technology Platforms

Platforms	Descriptions
SEM Platform	SEM is suitable for observing the surface morphology structure of samples, capable of obtaining three-dimensional surface images.
DLS Platform	DLS is used to measure particle size distribution and aggregation tendency, suitable for analyzing particles in liquid samples.

Our Advantages of Morphological Analysis for Nucleic Acid Drugs

Our services provide detailed three-dimensional structural information of nucleic acid molecules in different media, offering crucial data support for understanding their morphological characteristics and self-assembly behavior.
The morphological analysis of nucleic acid drugs combines multiple microscopy techniques, such as SEM, to comprehensively examine the nanoparticle characteristics of nucleic acid drugs.
Our analysis services can accurately measure parameters such as size, distribution, and shape of nucleic acid particles, providing a data foundation for subsequent research and application.
Support for real-time observation of morphological changes of nucleic acid drugs under different environments and conditions provides dynamic data for studying their stability and adaptability.

Publication Data

Technology: Morphological analysis of nucleic acid drugs utilizes electron microscopy.

Journal: Acta Pharmaceutica Sinica B

IF: 14.7

Published: 2022

Results:

DNA, a vital biopolymer, is responsible for encoding genetic data in living beings. Its precise nucleobase pairing facilitates the self-assembly of nanostructures, termed framework nucleic acids (FNAs), due to their structural properties. FNAs have recently gained traction across various scientific disciplines. This review emphasizes the pharmaceutical breakthroughs concerning FNAs. It highlights their benefits and roles in drug discovery, delivery, and analysis while also addressing their limitations and potential future research paths within the pharmaceutical landscape.

Fig.2 Structural appearance of carriers for nucleic acid drugs. Fig.2 Morphology of nucleic acid drug carriers. (Chen L, et al., 2022)

For further information on our nucleic acid drug morphological analysis services or any inquiries and needs, please feel free to contact us. Our professional team will provide timely consultation and support to ensure your research work progresses smoothly.

References

Chen L, Zhang J, Lin Z, et al. Pharmaceutical applications of framework nucleic acids. Acta Pharm. Sin. B. 2022, 12(1): 76-91.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

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STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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