Sulphated Peptide Synthesis

Since sulfated peptides have different stabilities under different conditions, the efficient synthesis of sulfated peptides is technically challenging. Thanks to decades of experience in peptide modification and synthesis, CD Formulation has developed a mature sulfated peptide synthesis program that combines advanced synthesis methods and optimized reaction conditions to ensure that sulfated peptides of high purity and stability are obtained under different conditions.

The Importance of Peptide Sulfation Modification

Sulfation is another post-translational protein modification (PTM) of proteins and peptides. Tyrosine O-sulfation is the most common and important process for proteins and peptides and is ubiquitous in peptides and proteins of multicellular eukaryotes. The mechanism revealed by this PTM involves tyrosine protein sulfotransferase (TPST), which is responsible for the transfer of a sulfate group (-SO₄) to the hydroxyl group (-OH) of tyrosine to form tyrosine-4-sulfate. Studies have shown that tyrosine O-sulfation plays an important role in enhancing protein-protein interactions and is involved in a variety of biological processes. The hydroxyl group of tyrosine is the main site of sulfation, in addition to serine (Ser) and threonine (Thr) sulphation.

Fig. 1 Tyrosine O-sulfation catalysed by TPSTs. (Stone MJ, et al., 2009)

Explore Our Custom Sulfated Peptide Synthesis Services

As experts in peptide modification, CD Formulation provides unparalleled peptide sulfation services to customers around the world. We have reliable synthesis procedures and excellent peptide analysis technology to solve any possible challenges in the development and production of peptide therapeutics.

Our team of peptide experts can handle the synthesis needs of a variety of sulfated peptides listed below.

• Tyrosine O-Sulfation
• Serine (Ser) Sulfation
• Threonine Sulfation

Considering the stability characteristics of tyrosine sulfated peptides, which are stable under alkaline conditions but unstable under acidic conditions. Our peptide synthesis experts have developed a mature sulfated peptide synthesis procedure and conducted in-depth research on the stability of tyrosine sulfated peptides under different pH conditions.

• Under alkaline conditions, our synthesis procedure can effectively maintain the integrity of the peptide chain and ensure that the sulfation modification is not destroyed.
• At the same time, we have also developed protection strategies adapted to acidic conditions to prevent the degradation of tyrosine residues in acidic environments. These strategies include the use of specific protecting groups and the optimization of synthesis conditions to ensure the quality of peptides during synthesis and storage.

Available Amino Acids for Custom Sulfated Peptide

Amino Acid Name	Structural Formula
Tyr(SO3H)
Thr(SO3H)
Ser(SO3H)

Peptide Manufacturing & Analytical Services

In addition to peptide synthesis capabilities, CD Formulation combines flexible GMP manufacturing facilities with cutting-edge peptide analytical knowledge to provide a full range of quality control testing services to accelerate the commercialization of your products, including:

Publication

CD Formulation has extensive experience with each sulfation modification of peptides. Please don't hesitate to contact us if you are interested in our services, and to learn more about the possibilities of incorporating sulfation into your peptides. We look forward to cooperating with you.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.