Oral thin film size is determined based on active pharmaceutical ingredient (API) solubility and a required drug dose. High drug loading could negatively affect the physical properties of oral thin films, such as thickness, disintegration time, and mechanical properties, or lead to recrystallization of the amorphous API. During the disintegration of an oral thin film, insoluble particles also could negatively affect the perception in the mouth. When an API with poor solubility is used to prepare an oral thin film, it is first necessary to increase its solubility. Solid dispersion is a technique that improves the solubility and dissolution rate of poorly water-soluble drugs, and it is the most frequently and effectively used one. CD Formulation provides solid dispersion technology to help customers increase the solubility of insoluble APIs, improve the drug load of oral thin films, and help customers develop oral thin films with high drug load.

Fig.1 Solid dispersion preparation method. (Randa Mohammed Zaki, et al., 2023)

Preparation Methods of Solid Dispersion

The methods used to prepare solid dispersion include melting method, solvent method and mechanical dispersion method. CD Formulation relies on our advanced design concept to use the following preparation methods to prepare solid dispersion, improve the dissolution of insoluble APIs, and support the development of oral thin film products.

Melting Method

The melting method is to prepare the drug and the carrier proportionately into a low eutectic or solid solution, and then rapidly cool it to form a solid dispersion. This process often has high requirements for API and carriers, requiring API and carrier to melt simultaneously or API to dissolve in the melted carrier, and the two cannot be degraded.

Solvent Method

The solvent method is the most traditional method for preparing solid dispersion. The carrier and API are dissolved in a benign solvent, and then the solvent is evaporated to obtain a solid dispersion.

Mechanical Dispersion Method

The mechanical dispersion method highly disperses the drug particles in the carrier through strong mechanical energy. The mechanical pulverizer can crush the particle size to less than 10 microns, the airflow pulverizer can crush the particle size to less than 5 microns, and the homogenizer can control the particle size to less than 1 micron.

Our Analytical Capabilities for Solid Dispersion

To characterize and assess the feasibility of the solid dispersions, we can provide you with the following characterization of solid dispersions including:

Workflow of Oral Thin Film Solid Dispersion Preparation

Fig.2 Workflow of Oral Thin Film Solid Dispersion Preparation. (CD Formulation)

Explore the Characterization of Solid Dispersion Oral Thin Film

We offer a range of solubilization technologies designed to enhance the solubility and bioavailability of poorly water-soluble drugs, facilitating the development of more effective oral thin film products. At the same time, we provide a range of characterization services for solid dispersion oral thin film.

Advantages of Our Solid Dispersion Oral Thin Film Preparation Technology

• We are very experienced in the formulation development of oral thin films containing solid dispersions and can efficiently characterize solid dispersions and oral thin films.
• Our oral thin film solid dispersion preparation technology is designed to significantly improve poorly water-soluble drugs' solubility and dissolution rate, leading to increased bioavailability.
• Our technology helps improve the stability of the drug, protecting it from degradation and enhancing the shelf-life of the medication.

Published Data

CD Formulation has extensive experience in solubilizing insoluble drugs and can provide solid dispersion solutions to meet customer needs. If you require our solid dispersion oral thin film preparation technology services, please contact us by phone or email, and our colleagues will get back to you within three working days.