Solid Dispersion Extrusion Technology for Oral Thin Film Manufacturing

Solid dispersion extrusion technology is to extrude the immiscible components with the drug to obtain a stable dispersion. Finally, dies are used to transform the stable dispersions into films. CD Formulation has many years of experience in solid dispersion extrusion technology for oral thin film manufacturing, and we can quickly help customers solve the possible problems in this preparation technology and speed up the development of oral thin films.

Fig.1 Preparation of fast-dissolving buccal film solid dispersion. (PARVEEN FAROOQUI, et al., 2023)

Process of Solid Dispersion Extrusion Technology for Oral Thin Film Manufacturing

In this method, the drug is dissolved in a suitable liquid solvent, and the solution is incorporated into the melt of polyols, such as polyethene glycol, obtained below 70 ℃. Without removing the liquid solvent, the solid dispersions are shaped into films using dies. The workflow of solid dispersion extrusion technology for oral thin film preparation is as follows:

Fig.2 Workflow of Solid Dispersion Extrusion Technology for Oral Thin Film Manufacturing. (CD Formulation)

Preparation Methods of Solid Dispersion

Solid dispersion extrusion technology is a method for manufacturing oral thin films using the solid dispersion method. The methods used to prepare solid dispersion include the melting method, solvent method and mechanical dispersion method. CD Formulation relies on our advanced design concept to use the following preparation methods to prepare solid dispersion, improve the dissolution of insoluble APIs, and support the development of oral thin film products.

Melting Method

The melting method is to proportionate the drug and the carrier into a low eutectic or solid solution and then rapidly cool it to form a solid dispersion.

Solvent Method

The solvent method is the most traditional method for preparing solid dispersion. The carrier and API are dissolved in a benign solvent, and then the solvent is evaporated to obtain a solid dispersion.

Mechanical Dispersion Method

The mechanical dispersion method highly disperses the drug particles in the carrier through strong mechanical energy. The mechanical pulverizer can crush the particle size to less than 10 microns, the airflow pulverizer can crush the particle size to less than 5 microns, and the homogenizer can control the particle size to less than 1 micron.

Explore Preparation Process of Solid Dispersion Extrusion Technology for Oral Thin Film

We use innovative solid dispersion extrusion manufacturing processes, which are fully scalable and efficiently meet demands. At the same time, we can characterize the dispersion, pay close attention to its state changes, and ensure the production of high-quality oral thin film products.

Advantages of Solid Dispersion Extrusion Technology

• Solid dispersion extrusion technology can enhance the solubility of poorly soluble drugs, allowing for better absorption and bioavailability.
• The extrusion process ensures an even drug distribution within the film, leading to consistent dosing and efficacy.
• Solid dispersion extrusion is a relatively quick and efficient manufacturing technology, leading to faster production times and reduced time-to-market for oral thin film.

Published Data

CD Formulation provides support and solutions for solid dispersion extrusion technology to help customers develop and optimize oral thin film products. We can offer a full range of oral thin film product development and testing based on our current technology and testing capabilities. If you require our solid dispersion extrusion technology for oral thin film manufacturing services, please contact us by phone or email, and our colleagues will get back to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.