Semi-solid Casting Technology for Oral Thin Film Manufacturing

When acid-insoluble polymers are used to prepare oral fast soluble films, semi-solid casting technology is usually preferred, and it is an emerging technology. In the semi-solid casting techniques, taste-masking agents are laminated, which provides excellent thickness uniformity and thin films prepared with a delicate glossy look and better physical properties. CD Formulation has established a complete semi-solid casting technology platform and is committed to creating high-quality oral thin films.

Manufacturing Technologies of Oral Thin Films

The manufacturing techniques of the oral thin film include solvent casting technology, semi-solid casting technology, hot-melt extrusion technology, solid dispersion extrusion technology, rolling technology, 3D printing technology, etc., among which, the preparation process of semi-solid casting technology and solvent casting technology is the same when acid insoluble is acid insoluble, semi-solid casting technology is usually preferred.

Fig.1 Flowchart of processes involved in the preparation of oral thin films. (Ahmad Salawi, 2022)

Advantages of Semi-solid Casting Technology

The advantages of semi-solid casting technology to prepare oral thin film are that it does not require expensive equipment, simplifies the casting process, has fast solidification speed, is easy to process in batches, and has an accurate thickness and pleasing appearance.

Principle of Semi-solid Casting Technology

The principle of semi-solid casting technology for oral thin film preparation is to prepare a solution of water-soluble film-forming polymer; the resulting solution is added to a solution of acid-insoluble polymer (e.g. cellulose acetate phthalate, cellulose acetate butyrate), which was prepared in ammonium or sodium hydroxide. Then, an appropriate amount of plasticizer is added to obtain a gel mass. Finally, heat-controlled drums cast the gel mass into the films or ribbons.

Fig.2 The principle of semi-solid casting technology for oral thin film manufacturing. (CD Formulation)

Explore Oral Thin Film Development Services Using Semi-Solid Casting Technology

We have conducted in-depth research on oral thin film formulation development using semi-solid casting technology. With the advanced semi-solid casting technology platform, we provide customized formulation development services for oral thin film, including quick-release oral thin film development, sublingual thin film development, fast disintegrating buccal film development, etc.

Why Choose CD Formulation?

• We use innovative semi-solid casting manufacturing processes, which are fully scalable and efficiently meet demands.
• We have many years of experience in semi-solid casting production of oral thin film, and we can quickly help customers solve the possible problems with this preparation technology and speed up the development of oral thin film.
• We have an advanced analysis and characterization technology platform that can provide comprehensive characterization services for preparing oral thin films using semi-solid casting technology, laying the foundation for producing high-quality oral thin films.

Published Data

CD Formulation can help you solve any problems that arise in semi-solid casting technology to prepare the oral thin film. If you require our semi-casting casting technology for oral thin film manufacturing services, please contact us by phone or email, and our colleagues will get back to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.