Semi-solid Casting Method for Oral Thin Film Preparation

The semi-solid casting method is an emerging technology in personalized medicine. This method involves adding a water-soluble film-forming material solution to an acid solution of a water-insoluble polymer, then adding a plasticizer to obtain a colloidal substance, which is subsequently melted and cast into a film-forming agent. The CD Formulation R&D team has established a complete semi-solid casting technology platform and is committed to creating high-quality oral thin films.

The Advantages of the Semi-solid Casting Method for Oral Thin Film Preparation

• The thickness of the thin film is highly accurate.
• The appearance of the thin film is good.
• Simplify the casting process and reduce energy consumption.
• Fast solidification speed and high productivity.

Semi-solid Casting Method Process for Oral Thin Film Preparation

When acid-insoluble polymers are used, the semi-solid casting method is generally used. The method prepares a water-soluble film-forming polymer solution, which is then poured into an acid-insoluble polymer solution prepared in sodium hydroxide or ammonium hydroxide. The plasticizer is added to form a gel group. The additional amount of plasticizer affects the properties of gel clumps. Gel blobs are formed and then cast into films or strips using a heat control roll/drum. The ratio of acid-insoluble polymer to film-forming polymer should be 1:4. The thickness of the film formed by this method is about 0.015 to 0.05 inches.

 Fig.1 Workflow of Semi-solid casting method for oral thin film preparation. (CD Formulation)

Why Choose Us for Preparing Oral Thin Films with the Semi-solid Casting Method?

• Scalable and Innovative Manufacturing: We use state-of-the-art, innovative semi-solid casting manufacturing processes, which are fully scalable, and efficiently meet commercial demands.
• Patient-Centric Design & Patient Compliance: our oral thin films are developed with a focus on patient comfort and convenience, ensuring easy integration into daily routines without disrupting lifestyle choices. The user-friendly nature of oral films, coupled with the potential for flavor enhancement, significantly improves patient adherence to medication regimens.
• Rich Experience: We have many years of experience in semi-solid casting production of oral thin film, we can quickly help customers solve the possible problems in this preparation technology and speed up the development of oral thin film.
• Flexibility: Flexible production capacity can meet the production needs of different scales and types.

Published Data

CD Formulation can help you solve any problems that arise in the semi-solid casting method to prepare the oral thin film. If you have a requirement about our semi-solid casting method for oral thin film preparation services, please contact us by phone or email, and our colleagues will reply to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.