Rolling Technology for Oral Thin Film Manufacturing

The rolling method is a technique used to manufacture oral thin films. The process involves rolling a drug solution or suspension onto a carrier roller, drying the resulting film, and cutting it into the desired shapes and sizes. CD Formulation has many years of experience in rolling technology for oral thin film manufacturing, so we can quickly help customers solve possible problems with this technology and speed up the development of oral thin films.

Principle of Rolling Technology

In the rolling process, the premix is first prepared, the active ingredient is added, the solution or suspension containing the drug is rolled on a carrier, and the film is formed. Premix batch components fed to the master batch feed tank include film-forming polymer, polar solvent, and other additives besides API. Then, the master batch is supplied in a specified quantity using a metering pump and control valve. The necessary drug quantity is introduced to the mixer and mixed long enough to form a homogenized matrix. A precise amount of matrix is pumped into the pan via a second metering pump. The metering roll determines the thickness of the film. Finally, the film is created on the substrate and removed by the support roller.

Fig.1 Three rolling coating units. (Arun Arya, er al., 2010)

Advantages of Rolling Technology for Oral Thin Film Manufacturing

• The better surface finish obtained
• No heating required
• Improved strength properties

Process of Rolling Technology for Oral Thin Film Manufacturing

The rolling technique involves rolling a drug solution or suspension onto a carrier roller, drying the resulting film, and then cutting it into the desired shapes and sizes. The workflow of rolling technology for oral thin film preparation is as follows:

Prepare the Premix

Add the film-forming polymer, polar solvent, and other excipients to a feed tank, except for the active ingredient (API).

Dissolve the API

A high-shear processor dissolves the API and other components in a small amount of aqueous solvent, usually water or a water/alcohol mixture.

Roll the Solution

Thoroughly mix the drug and film-forming polymer solutions, then feed the solution with the intended dose to the roller using a controlled valve pump. The solution should have specific rheological considerations.

Dry the Film

Dry the film on rollers.

Cut the Film

Cut the film into the desired shapes and sizes.

Explore Preparation Methods for Oral Thin Films

We specialize in providing comprehensive contract research and development services for oral thin film formulations. With over decades of industry experience, our team excels in exploring and optimizing preparation methods for oral thin films. We meticulously evaluate and select the most appropriate and effective techniques for producing high-quality thin films.

Why Choose CD Formulation?

• Our rolling technology can be easily scaled up to meet large-scale production demands, making it suitable for manufacturing.
• Our rolling technology is cost-effective, as it requires minimal energy and resources to operate, helping to reduce production costs.
• Our rolling technology is versatile and can accommodate a variety of formulations, allowing for the production of different types of oral thin films with varying properties.

Published Data

CD Formulation has advanced rolling technology for oral thin film manufacturing, which allows for precise control over the thickness of the oral thin films, ensuring consistency and accuracy in manufacturing. If you require our rolling technology for oral thin film manufacturing services, please contact us by phone or email, and our colleagues will get back to you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.