Oral Thin Film Efficacy Evaluation
Inquiry
Oral thin films have gained great appeal in the pharmaceutical industry due to their ease of use, rapid disintegration, and high bioavailability. However, traditional oral drug efficacy evaluation methods are often limited by the inability to accurately measure drug concentrations in the body, which poses challenges in accurately evaluating the efficacy and safety of these films. With the launch of CD Formulation's efficacy evaluation services, our technical teams can analyze drug release kinetics, bioavailability, and pharmacokinetics of oral thin films with unprecedented precision by combining cutting-edge analytical technologies.
Fig.1 Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation (Anroop B, et al., 2021)
Clinical Advantages of Oral Thin Films
- As oral thin films are given by oral route their administration is easy as it employs the oral route.
- In paediatric and geriatric patients, the risk of choking or suffocation is reduced.
- Oral Thin Films are a better alternative for patients with nausea.
- Oral Thin Films do not require to be swallowed with water.
Our Oral Thin Films Efficacy Evaluation Services
In general, CD Formulation provides oral thin films efficacy evaluation project include but not limited to the following processes:
We conduct extensive preclinical studies to provide reliable data support for the next stage of development of oral thin films by evaluating factors such as drug release kinetics, absorption, metabolism, and possible toxicity in the preclinical stage to determine the safety and efficacy of oral thin films.
At this stage, we use advanced analytical techniques such as mass spectrometry and biomarkers to carefully evaluate the absorption, distribution, metabolism, and excretion of oral thin films, understand the behavior of drugs in the body, analyze pharmacodynamic responses to evaluate the expected therapeutic effect, and provide guidance for further formulation optimization and clinical administration.
The transport of drugs through any membrane is regulated by the properties of the drug molecules and the basic physiology of the biological barrier. We usually conduct in vitro permeation experiments to understand the absorption kinetics of drugs through biofilms and conduct in vivo performance evaluation of oral thin films through animal experiments. Efficacy evaluation of oral thin films ensure optimal drug release, bioavailability, and pharmacokinetic profile to improve patient experience and treatment outcomes.
Our Platforms for Oral Thin Film Efficacy Evaluation
| Techniques & Platform |
Specifics Contents |
| Preclinical Study Platform |
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals. Our preclinical study services are composed of three parts: pharmacokinetics, disease animal models, and drug safety evaluation, covering protocol design, in vivo studies, sample analysis, professional data analysis, IACUC review, etc., and application preparation. |
| Pharmacokinetic Study Platform |
Our pharmacokinetic experimental study follows the guiding principles of ICH and FDA and can design and carry out in vivo and in vitro pharmacokinetic tests according to customer needs, providing customers with a complete set of pharmacokinetic evaluation and optimization services. |
| Pharmacodynamic Study Platform |
The main experimental contents of our pharmacodynamic study include in vitro test (biochemical test, cell test, etc.) and in vivo test (whole animal test). In vivo pharmacodynamic studies, we focus on the selection of animal models. |
Our Advantages in Oral Thin Film Efficacy Evaluation
- Comprehensive Efficacy Evaluations: We conduct rigorous pharmacokinetic, pharmacodynamic, bioavailability and overall therapeutic efficacy studies to evaluate the safety and effectiveness of oral thin films.
- Rigorous Regulatory System: We implement strict quality control and supervision systems throughout the entire oral thin films development and efficacy evaluation process.
- Specialized Research Team: We have very rich experience in efficacy evaluating of oral thin films. By the efficacy evaluation of oral thin films, we can effectively judge the therapeutic effect and safety of drugs on specific diseases.
Efficacy evaluation of oral thin films is an important part of the development of oral thin film drug delivery systems. By the efficacy evaluating of drugs, the effectiveness and safety of specific diseases can be judged, helping researchers to promote research on oral thin film drug delivery systems. If you have a requirement about our oral thin film efficacy evaluation services, please contact us by phone or email, our colleagues will reply to you within three working days.
References
- Emrah Özakar, Rukiye Sevinç-Özakar, et al. Preparation, Characterization, and Evaluation of Cytotoxicity of Fast Dissolving Hydrogel Based Oral Thin Films Containing Pregabalin and Methylcobalamin. Gels. 2021,9 (2):147.
- Anroop B. Nair, Jigar Shah, et al. Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation. Pharmaceutics. 2021, 13(5):728.
How It Works
STEP 2
We'll email you to provide your quote and confirm order details if applicable.
STEP 3
Execute the project with real-time communication, and deliver the final report promptly.
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