Poor aqueous solubility is a significant issue in many pharmaceutical industries. By some estimation, 70–90% of drug candidates are in the development stage, while up to 40% of the marketed products are poorly soluble, which leads to low bioavailability, reduced therapeutic effects and dosage escalation. The development of oral-dissolved films containing insoluble APIs is limited due to the small size of the oral thin films. Recently, "Nanotechnology" has become very important and widely utilized in the modern pharmaceutical industry to solve the bioavailability problem of poorly water-soluble drugs. CD Formulation provides professional nanoparticle preparation technology to prepare insoluble drugs as nanoparticles to increase their low water solubility and low bioavailability and load them as an oral thin film.

Fig.1 Formulation and characterization of fast-dissolving oral films containing nanoparticles. (Kanchan Bharti, et al., 2019)

Preparation Methods of Nanoparticles

After poorly soluble APIs are made into nanosuspensions, not only can the particle size of the drugs be reduced and the specific surface area of the drugs be increased, but also the solubility of the poorly soluble drugs can be increased, thereby improving the bioavailability of the drugs. The preparation methods of nanosuspension mainly include nanoprecipitation, high-pressure homogenization, medium grinding, emulsification, etc.

Our Analytical Capabilities for Nanoparticles

To characterize and assess the viability of the nanoparticle, we can provide you with the following characterization of the nanoparticle including:

• Determination of Zeta Potential
• Zeta Potential
• Particle Size Distribution
• Entrapment Efficiency
• In-vitro Dissolution
• Crystallinity and Surface Morphology
• In-vitro Dissolution Study of Oral Thin Film Incorporating Nanoparticle
• Stability

Our Workflow of Nanoparticle Oral Thin Film Preparation

Our nanoparticle oral thin film preparation technology generally includes the following steps:

• Screening of the Components for Formulation of Blank Oral Thin Film
  We screen suitable film-forming agents, plasticizers, sweeteners, etc. We typically use a Central composite design to select film compositions with desirable properties.
• Preparation of Nanoparticle
  According to the characteristics of API, we select an appropriate nanoparticle preparation method to prepare nanosuspension and investigate the effects of different variables on nanoparticles.
• Nanoparticles Characterization
• The Preparation of Nanoparticle Oral Thin Film
  We screen suitable preparation methods to prepare nanoparticle oral thin films.
• Oral Thin Film Characterization

Fig.2 The Preparation of oral thin film nanoparticle strips. (Dikshita Ullas Chavan, et al., 2020)

Advantages of Our Nanoparticle Oral Thin Film Preparation Technology

• We have a mature, standardized nanoparticle oral thin film preparation technology.
• The Box-Behnken design was constructed to develop and optimize the nanoparticle oral thin film.
• We use nanoparticle technology, considering stability, bioavailability, and controlled release factors.
• We assist in transferring our nanoparticle oral thin film preparation technology to our client's manufacturing sites, providing training and support to ensure a seamless transition.

Explore the Characterization of Nanoparticle Oral Thin Films

Our analysis team is familiar with the analysis of nanoparticles and various oral dissolved membranes, and we provide a range of characterization services for nanoparticle oral thin film.

Published Data

CD Formulation offers a range of solutions for developing and manufacturing oral thin films using nanoparticle technology. If you require our nanoparticle oral thin film preparation technology services, please contact us by phone or email, and our colleagues will get back to you within three working days.