Antihistamines Oral Thin Film Formulation Research

Oral thin film is a preparation of postage stamp size, with the advantages of flexible, tasty and without water for oral administration. CD Formulation offers comprehensive R&D solutions for the development of antihistamine oral thin films. Our services include formulation design and optimization, taste masking, API-excipient compatibility and stability studies, manufacturing process development, and analytical method establishment, ensuring a seamless and efficient development process.

Main Applications of Antihistamines Oral Thin Film

Allergic reactions can seriously affect people's life and even threaten their lives. Our R & D team is dedicated to develop antihistamines oral thin film for relieving allergy symptoms.

Applications	Detailed Information
Case 1: Prevent allergic disorders Fexofenadine HCL is an antihistamine that has inadequate oral bioavailability and limited aqueous solubility. We are trying to alleviate this limitation with the advantages of oral thin film.	Fig.1 Formulation development and optimization of oral fast-dissolving films. (Asmaa H. Abdelhameed, et al., 2023)
Case 2: For urticaria, rhinitis and asthma bronchial Cetirizine dihydrochloride buccal mucoadhesive is applied in the case of allergic reactions (urticaria or rhinitis) and asthma bronchial.	Fig.2 Formulation and Optimization Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride. (Krisztián Pamlényi, et al., 2021)
Case 3: Quick relief allergy symptoms Loratadine is a second-generation antihistamine that exhibits a low and variable oral bioavailability (10–40%) and delayed onset owing to poor solubility and an extensive first-pass effect. Leveraging oral thin film technology enables us to offer a wider range of potential solutions to this issue.	Fig.3 Bright field microscopy image of films composed of Loratadine (A) and Loratadine-citric acid co-amorphous systems (B). (Yahya Alhamhoom, et al., 2024)

Our Preparation Methods for Antihistamines Oral Thin Film

Oral thin film preparation methods include solvent casting method, hot melt extrusion method, inkjet printing technology, etc. Although each method has advantages and limitations, we can help our customers choose the right preparation method based on the properties of antihistamines.

Solvent Casting Method

Solvent casting is the most used preparation technology. The process is to dissolve polymers, plasticizers and other excipients in suitable solvents. Then, the antihistamine API is incorporated into the solution and the mixed solution is cast onto a substrate. Finally, the solvent is evaporated, cut, and packaged. 

Hot Melt Extrusion Method

Hot melt extrusion is a continuous processing technique. The antihistamine API, polymer, plasticizer, and other excipients are mixed and then subjected to controlled heat and pressure to form a homogeneous melt. The melt is then extruded through a die to form a thin film.

Inkjet Printing Technology

Inkjet printing technology can deposit precise amounts of a liquid formulation containing the antihistamine and other components onto a substrate, creating a thin film through the controlled deposition of droplets.

Custom Antihistamines Oral Thin Film Formulation Development

Our professional oral thin film experts and laboratory instruments can bring customers comprehensive technical support services and solutions to help you achieve the integration of antihistamines oral thin film development research to administration.

Why Choose CD Formulation?

• Tailored Solutions: Formulation of the antihistamines oral thin film involves the application of both aesthetic and performance characteristics such as strip-forming polymers, plasticizers, APIs, sweetening agents, saliva stimulating agents, flavoring agents, coloring agents, stabilizing and thickening agents, masking agents, rapid dissolution, physical appearance, taste, etc. We offer customized solutions, working closely with our customers to understand their needs and develop tailor-made solutions to meet their unique specifications.
• One-stop Solutions: We provide one-stop solutions for antihistamines oral thin film, with high-cost performance and competitive prices.

With extensive expertise in oral thin film technology, CD Formulation delivers innovative, end-to-end solutions to address the challenges and opportunities in antihistamine formulation development. Drawing on industry best practices, we support pharmaceutical companies and research institutions in creating cutting-edge drug delivery systems. For inquiries about our R&D services, please contact us via phone or email. Our team will respond within three business days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.