Zeta Potential Analysis Platform for Nucleic Acid Drugs

CD Formulation's Zeta potential analysis platform offers highly accurate measurements and detailed charge characterization data for a diverse array of nanocarriers. Our platform enables researchers to evaluate nanoparticle stability, optimize formulations, and analyze interactions with biological systems using advanced technologies.

About Zeta Potential Analysis Technology Platforms

Zeta potential measurement is a crucial tool for evaluating the surface electrical properties of particles in nucleic acid formulations. It allows for the determination of the solid-liquid interfacial electrical characteristics of particulate matter in a dispersed system, which is essential for understanding its stability and surface properties. A higher zeta potential indicates a greater repulsive force between particles, reducing the likelihood of agglomeration and thereby enhancing the stability of the system. Consequently, the stability of the system can be effectively assessed or predicted based on the magnitude of the zeta potential.

Fig.1 Schematic diagram of zeta potential. (CD Formulation)

Zeta Potential Analysis Methods for Nucleic Acid Drugs

Factors Affecting Zeta Potential Analysis

Effect of pH

Generally speaking, at low pH, the solvent environment contains a higher concentration of [H⁺] ions, resulting in particles that tend to be positively charged. Conversely, at higher pH levels, the solution has an increased concentration of [OH^-] ions, leading to particles that are typically negatively charged.

Effect of Salt Concentration

Adding salt to a solution increases its ionic strength, which is influenced by both the valence and concentration of the salt. As the valence and concentration of the salt increase, the ionic strength also rises, resulting in a stronger shielding effect on the surface potential of the particles. Consequently, this leads to a decrease in the zeta potential of the particles.

Influence of Particle Concentration

If the solution environment surrounding the particles remains constant and only the concentration of the particles is altered, the zeta potential does not vary within a lower concentration range. In this range, the detected zeta potential value accurately reflects the true zeta potential. However, once the particle concentration reaches a critical threshold, the zeta potential of most systems approaches zero.

Our Capabilities of Zeta Potential Analysis Platform for Nucleic Acid Drugs

CD Formulation's Zeta potential analysis platform can be utilized to analyze various types of nanocarriers designed for encapsulating nucleic acid drugs. The variations in zeta potential among different nanocarriers in diverse environments can aid in optimizing their performance for delivering nucleic acid drugs, thereby ensuring more efficient and safer delivery to target cells or tissues in vivo.

Liposome Nanoparticles

Zeta potential analysis can demonstrate the effective drug-carrying capacity of cationic liposomes for negatively charged nucleic acid drugs, owing to their positive charge.

Polymer Nanoparticles

Zeta potential measurements enable the assessment of the surface charge density of nanoparticles and their capacity to bind nucleic acid drugs. High zeta potential values typically indicate good stability and excellent encapsulation efficiency of these nanoparticles.

Inorganic Nanoparticles

Zeta potential measurements are essential for assessing the changes in surface charge of both modified and unmodified inorganic nanoparticles when encapsulating negatively charged nucleic acid drugs. The zeta potential can be tailored through surface modification to enhance biocompatibility and improve drug delivery efficiency.

Highlights of Zeta Potential Analysis Platform for Nucleic Acid Drugs

• We utilize advanced zeta potential analyzers to ensure high accuracy and repeatability of measurement results.
• Our platform can be utilized to study a diverse array of nanocarriers, including liposomes, polymer nanoparticles, gold nanoparticles, and quantum dots. It is especially well-suited for nanocarriers that encapsulate nucleic acid drugs.
• In addition to zeta potential, our platform can also synchronize the analysis of particle size, distribution, concentration, and other parameters, providing comprehensive data support for a thorough understanding of nanocarrier properties.
• According to various research requirements, we offer tailored zeta potential testing solutions, complemented by expert consultation to ensure the relevance and effectiveness of the research.

Our Analytical Characterization Services

CD Formulation's zeta potential analysis platform offers comprehensive zeta potential analysis services, particularly for nanocarriers coated with nucleic acid drugs.

Publication Data

CD Formulation's Zeta Potential Analysis platform is equipped with state-of-the-art equipment and a dedicated team of technicians to ensure high-quality data and results. Please feel free to contact us for more information on how we can enhance your drug discovery program.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.