Zeta Potential Analysis for Nucleic Acid Drugs

CD Formulation provides professional Zeta potential analysis services, specializing in the research and development of nucleic acid drugs. Our technology platform aids in gaining insight into the interfacial properties and dispersion stability of nucleic acid drugs under various conditions, thereby optimizing formulations and manufacturing processes.

Why Conduct Zeta Potential Analysis for Nucleic Acid Drugs?

Zeta potential analysis assists researchers in assessing the stability of nucleic acid drugs across different formulations and environments, a crucial consideration in formulation development. By testing the Zeta potential of nucleic acid drug particles, one can predict and control their physical-chemical behavior in biological systems, optimizing process formulations. Additionally, Zeta potential measurement reveals the electrostatic interactions between particles in different solution conditions, offering data support for improving interfacial properties and enhancing formulation quality. This analysis also helps identify the isoelectric point of the product, addressing potential particle aggregation issues to ensure product consistency and performance stability.

Methods of Zeta Potential Analysis

Electrophoretic Method

This involves injecting the test liquid into an electrophoretic cell with applied voltage, measuring colloidal particle migration velocity using laser doppler velocimetry, and calculating the Zeta potential from the relation between Zeta potential and mobility.

Streaming Potential Method

Common for detecting the Zeta potential on fibers or fillers' surfaces, this method provides a clear example of Zeta potential measurement using the streaming potential approach.

Explore Our Zeta Potential Analysis for Nucleic Acid Drugs

Zeta Potential Analysis of Different States of Nucleic Acid Drugs

Repeatability of Zeta Potential Analysis

Zeta potential repeatability is affected by factors such as potential size, ionic strength, light scattering intensity, turbidity, dispersion uniformity, and sedimentation effects.

Our Workflow of Zeta Potential Analysis for Nucleic Acid Drugs

Fig.1 Flow chart of nucleic acid Zeta potential analysis. (CD Formulation)

• Sample Preparation

Prepare samples based on the drug's physical and chemical properties to ensure accurate Zeta potential measurements.

• Equipment Calibration

Perform stringent equipment calibration, including checking electrode conditions and laboratory environment stability, to ensure data reliability.

• Zeta Potential Analysis

Inject samples into the analyzer post-calibration, recording and analyzing electrophoretic velocity for Zeta potential calculation.

• Data Analysis

Post-test data analysis involves calculating Zeta potential values and comparing them against models or historical data for stability assessment.

Our Technology Platforms

Our Zeta potential analysis platform measures particulate surface electricity, providing dispersal system data to evaluate and optimize stability. It supports various sample forms ensuring reliable charge density data across evolving formulations and processes.

Our Advantages of Zeta Potential Analysis for Nucleic Acid Drugs

• Detailed assessment of surface charge properties aids in understanding particle behavior in different formulations and during processing.
• Our services provide critical stability data for formulation optimization under various conditions, enhancing research and development efficiency.
• Quick analysis feedback supports research adjustments to experimental conditions and process routes, improving development efficiency.
• Our services Enable informed decision-making with scientific support, leading to data-driven and precise product development.

Publication Data

For further details on CD Formulation's Zeta potential analysis services or to receive personalized solutions, please contact our expert team for support and assistance.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.