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MSD Technology Platform for Nucleic Acid Drugs

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CD Formulation offers a cutting-edge MSD technology platform dedicated to the development and optimization of nucleic acid formulations. With our technical expertise and extensive experience, we provide comprehensive solutions to enhance the stability and bioavailability of nucleic acid therapeutics.

Advantages of Our Platform for Nucleic Acid Drugs

Meso Scale Discovery (MSD) technology offers precise quantification of biomarkers through electrochemiluminescence-based multiplexed immunoassays. Below are the advantages of our platform.

Higher Sensitivity and Broader Linear Range

MSD has a sensitivity of 0.05 pg/mL and an effective linear range of 6 log (from sub-picogram levels to tens of thousands of picograms).

High Sample Compatibility and Low Matrix Effect

The MSD platform is highly compatible with various types of biological samples due to its unique electrochemiluminescence principle, which minimizes non-specific signals and is less influenced by the characteristics of the sample.

Signal Stability

Since MSD relies on electrochemiluminescence, the signaling molecules must be electrically excited to generate a signal. Consequently, the entire process does not require light and remains unaffected by variations in the operator's skill level.

Open Platform

The graphite electrode plates utilized in the MSD platform are composed of polymerized materials featuring a three-dimensional structure both on the surface and internally. This design enhances the payload capacity by 10 to 100 times compared to conventional ELISA plates.

Our Capabilities of Our Platform for Nucleic Acid Drugs

Nucleic Acid Quantification	High-Throughput Sample Screening
MSD technology facilitates highly accurate quantitative analysis of nucleic acids, even in trace amounts.	Provides high-throughput testing services that align with clinical trials and mass screening, thereby shortening testing cycles.
Nucleic Acid Structure Analysis	Multi-Target Detection
Detecting the structure and sequence of nucleic acid molecules using MSD technology enables researchers to comprehend the functions of nucleic acids and to design novel therapeutic molecules.	Suitable for the multi-target detection of complex samples, this method allows for the simultaneous detection of multiple nucleic acid targets, thereby enhancing both detection efficiency and accuracy.

Applications of Our Platform for Nucleic Acid Formulations

CD Formulation's MSD technology platform is highly applicable across various fields of nucleic acid formulation.

Fig.1 Applications of our platform for nucleic acid formulations Fig.1 Applications of MSD technology platform. (CD Formulation)

Highlights of Our MSD Technology Platform for Nucleic Acid Drugs

Adopting the latest analytical methods, the MSD technology platform is capable of accurately detecting nucleic acid sequences and structures, thereby ensuring the accuracy and reliability of the results.
The platform is optimized for efficient nucleic acid analysis, significantly reducing experimental time and enhancing overall work efficiency.
Using advanced detection instruments and reagents, the platform can detect trace amounts of nucleic acid samples, making it suitable for the analysis of low-abundance specimens.
The MSD technology platform is compatible with various nucleic acid sample types, including DNA and RNA, and is suitable for numerous application scenarios.

Our Analytical Characterization Services

CD Formulation employs advanced MSD technology to deliver high-quality analyses that support biomedical research and drug development.

Nucleic Acid Drug Immunogenicity Testing

MSD technology is utilized in immunogenicity assays to assess whether a drug or biologic will elicit an immune response in the body. This evaluation is crucial for determining the safety and efficacy of drugs.

Nucleic Acid Drug Biomarker Testing

In drug development, the detection and analysis of biomarkers can assist scientists and physicians in understanding disease progression, evaluating treatment efficacy, and predicting patient responses.

Pharmacokinetics (PK) Assays for Nucleic Acid Drugs

The MSD platform facilitates the accurate detection and quantification of drug concentrations and their metabolites within the body, assisting scientists in understanding the absorption, distribution, metabolism, and excretion characteristics of drugs.

Pharmacodynamics (PD) Assays for Nucleic Acid Drugs

By utilizing MSD technology, multiplexed analyses can be conducted with very low background signals and assays that have a wide dynamic range. This allows for the assessment of the effects and mechanisms of drugs at various dosage levels.

Nucleic Acid Drug Toxicology Analysis

MSD technology facilitates the evaluation of drug and chemical toxicity. This is especially crucial in the development of new drugs and toxicity testing to ensure their safety.

Publication Data

Technology: Meso Scale Discovery technology for detecting antibodies

Journal: Journal of Veterinary Diagnostic Investigation

IF: 1.2

Published: 2012

Results:

A multiplex enzyme-linked immunosorbent assay (ELISA) was developed on the MSD platform to detect antibodies to bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BHV-1), bovine parainfluenza virus 3 (BPV-3), and bovine respiratory syncytial virus (BRSV). This multiplex ELISA test uses the same antigens (relatively crude cultured virus lysates) as are currently used in separate in-house ELISA tests. The use of multiplex ELISA can provide significant benefits to routine serologic testing by reducing staff time, lowering reagent costs, and simplifying laboratory operations.

Fig.2 Meso Scale Discovery technology for detecting antibodies Fig.2 Curve analysis of the Meso Scale Discovery multifunctional test. (Mayers J, et al., 2012)

With CD Formulation's MSD technology platform, precise analysis and testing of nucleic acid formulations not only enable real-time monitoring of formulation quality but also provide robust support for nucleic acid drug development. Contact us anytime for professional and efficient assistance with your research and applications using our MSD technology platform.

References

Mayers J, Sawyer J. Development and evaluation of a multiplex enzyme-linked immunosorbent assay for the detection of antibodies to bovine respiratory diseases on the Meso Scale Discovery platform. J VET DIAGN INVEST. 2012, 24(4): 725-729.

How It Works

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Submit a service request describing your specific research or development need.

STEP 2

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STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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