Pharmacodynamic (PD) Assays for Nucleic Acid Drugs

Pharmacodynamics is becoming increasingly valuable in assessing drug activity and target modulation in clinical trials. CD Formulation integrates state-of-the-art technology with industry-leading PD expertise to provide comprehensive PD analytical testing. Our scientific team has the necessary expertise and capabilities to provide a total solution for PD analysis, with a focus on innovative research.

Why Pharmacodynamics Assays for Nucleic Acids?

Pharmacodynamics (PD) is the study of the biochemical, physiological and molecular effects of nucleic acid drugs on the human body, involving receptor binding, post-receptor effects and chemical interactions. It is a study of how a drug affects an organism. In order to better evaluate and optimize nucleic acid drugs, it is necessary to carry out in-depth PD analysis studies to comprehensively analyze the dynamic process of the drug in the body by detecting changes in its concentration in the target organ or target cell, as well as changes in the relevant pharmacological indicators. Only in this way can we provide a more accurate and reliable basis for the optimization of clinical drug regimen.

Fig.1 MIDO is a PK/PD method that can be used to identify information-rich markers. (Luterbach C L, et al., 2022)

Explore Our Nucleic Acid Pharmacodynamic Assays Services

Pharmacodynamic studies determine how drugs and substances affect biological systems in organisms, understand how drugs modulate target receptors and cellular pathways, and analyze the biological processes they undergo. CD Formulation's core team of pharmacologists is experienced in conducting in vivo PK studies, and our PD studies allow us to provide valuable insights into the behavioral or psychological effects of drugs in organisms. PD studies allow us to provide valuable insights into the behavioral or psychological effects of drugs in organisms, while seamlessly integrating multiple assays to meet your specific requirements and needs.

In vivo pharmacodynamics studies will provide insights into the mechanism of action, potency and efficacy of a drug, as well as a wide range of other support for drug development, including the following service offerings.

Our Advanced Pharmacodynamic Assays Platform for Nucleic Acids

We are experts in developing and validating assays to assess PD behavior at all stages of the drug development process using the following platforms.

Our Workflow for Nucleic Acid Drugs Pharmacokinetic Assays

Fig.2 Flow chart of nucleic acid drugs pharmacokinetic assays. (CD Formulation)

Experimental Design

Craft a comprehensive experimental protocol tailored to the study's objectives. This includes the careful selection of suitable cell models and relevant biomarkers to ensure precise and meaningful results.

Sample Processing

Obtain cell or tissue samples at designated time points. Apply necessary pre-treatment processes to prepare the samples adequately for further analysis.

Detection & Analysis

Employ a variety of biochemical, immunological, or molecular biological methods to accurately measure and analyze the expression levels or activities of key biomarkers.

Reporting of Results

Utilize multiple biochemical, immunological, and molecular biological techniques to assess and report the expression levels or activities of the relevant biomarkers.

Why Choose Us for Nucleic Acid Drugs Pharmacodynamic Assays?

• Our scientific team has extensive expertise in a range of assays, including the measurement of soluble biomarkers and molecular events, to ensure reliable and reproducible results.
• We have successfully developed, optimized and validated our PD assay services for a variety of regulatory conditions.
• Our services are fully compliant with clinical and laboratory standards for determining minimum inhibitory concentration (MIC), antimicrobial drug dosing intervals, drug combinations, and antimicrobial drug concentrations in relation to microbial growth rates.

Publication Data

Based on our extensive experience, CD Formulation can support your nucleic acid formulation development program from start to finish, with fast cycle times and the latest innovations. We can design appropriate pharmacokinetic studies and complete pharmacokinetic calculations. Our high quality PD analysis services will greatly contribute to the success of your project. Please feel free to contact us for more information and a detailed quote.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.