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ICP (Inductively Coupled Plasma) Technology Platforms

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CD Formulation uses its cutting-edge ICP (Inductively Coupled Plasma) platform to deliver comprehensive elemental analysis solutions, aiding the research and quality control of nucleic acid drugs. Our advanced ICP technology precisely detects and quantitatively analyzes trace elements in drug formulations, thereby safeguarding the products' safety and efficacy.

Features of ICP Analysis Technology

Comprehensive Multi-Element Detection Capability

ICP technology can detect multiple elements simultaneously in a single operation, significantly enhancing analysis efficiency and meeting the extensive element detection needs in nucleic acid drugs.

High Sensitivity and Ultra-Low Detection Limits

By recognizing and quantifying trace elements at ng/g levels, ICP technology ensures the purity and safety standards of nucleic acid drugs at any manufacturing stage.

Outstanding Selectivity for Distinguishing Chemically Similar Elements

With precise spectroscopic technology, ICP can easily distinguish and identify chemically similar elements, effectively resolving complex issues in the component analysis of nucleic acid drugs.

Broad Linear Detection Range for Different Concentration Needs

Its wide linear detection range allows ICP technology to adapt to different detection needs from trace to high concentration levels, becoming a powerful tool in the analysis of complex samples in nucleic acid drugs.

High Accuracy and Excellent Repeatability

Through strict error control, ICP technology achieves a relative error of less than 1%, providing a reliable data foundation for quality assurance and consistency testing of nucleic acid drugs.

Types of ICP Technology Platforms

Platforms	Descriptions
ICP-OES (Optical Emission Spectroscopy) Platform	The ICP-OES platform uses a high-temperature plasma source to excite samples, dispersing emitted spectra through an optical system for simultaneous identification and quantitative analysis of multiple elements. It is widely used in nucleic acid drugs due to its superior detection sensitivity and linear range for higher concentration elements, providing precise component analysis in both research and production quality control.
ICP-AES (Atomic Emission Spectroscopy) Platform	ICP-AES is well-suited for detecting multiple elements in complex samples, relying on high-resolution optical technology for detailed atomic emission spectrum analysis. In nucleic acid drugs, it effectively distinguishes and identifies chemically similar elements to ensure impurity-free medications, enhancing product purity and efficacy.
ICP-MS (Mass Spectrometry) Platform	Combining the advantages of inductively coupled plasma and mass spectrometry, ICP-MS offers extremely sensitive detection capabilities to identify and measure isotopes and trace elements at very low levels in samples. By detecting mass numbers, it provides high precision analysis for nucleic acid drug research requiring ultra-trace element information, suitable for rigorous analysis and safety assessments of complex formulations.

The Process of ICP Analysis

Fig.1 ICP Analysis Workflow. Fig.1 Workflow of ICP Analysis. (CD Formulation)

Sample Introduction and Atomization

Liquid samples are transformed into fine aerosols via a nebulizer, delivered with high-purity argon gas into the plasma torch for stable sample delivery.

Plasma Generation and Sample Excitation

A high-frequency power source generates a powerful electromagnetic field on a quartz torch coil, ionizing argon gas to form high-temperature plasma where samples are thoroughly vaporized, atomized, and partly ionized.

Atom or Ion Emission of Light

Under high-temperature plasma, atoms or ions in the sample are excited to emit characteristic radiation, producing unique spectral signals as outer electrons return to their ground state.

Spectral Separation

Emitted light is decomposed by a spectrometer into spectra arranged by wavelength for qualitative element analysis by detecting these wavelengths.

Light Intensity Measurement and Quantitative Analysis

Photosensitive devices accurately measure the intensity of light at different wavelengths, performing element quantitative analysis based on emission spectrum intensity for identification and concentration determination.

Data Processing

Finally, collected spectral data is processed and analyzed by a computer system, converting into specific elemental information and concentration values in the sample, providing a detailed basis for further research and study.

ICP Testing Precautions

ICP testing requires attention to sample preparation and handling. Samples should be neutral or slightly acidic clear solutions, especially avoiding fluoride ions and organic solvents, as they may affect ICP detection accuracy. Additionally, the sample introduction system needs to remain clean to prevent cross-contamination, crucial for maintaining consistency and accuracy in detection.

Sample Preparation Requirements for ICP

Items	Descriptions
Liquid Samples	Liquid samples should be neutral or slightly acidic clear solutions, avoiding organic solvents and fluoride ions, and provide at least 3-5 mL.
Solid Sample Handling	Solid samples are usually dissolved in acid to ensure complete conversion into measurable solutions; melting or arc methods can be used if necessary.
Sample Purity Control	Avoid cross-contamination by ensuring all utensils are clean, with the sample's true composition free from external interference.
Concentration Preparation Standardization	Prepare liquid samples to a suitable concentration range, ppm level for ICP-OES and ppb level for ICP-MS.

Highlights of the ICP Platform

Equipped with advanced spectrometers and detectors, the ICP platform ensures high accuracy in every analysis.
Our platform employs automated sample handling and analysis processes, greatly enhancing efficiency and reducing human error.
Our platform features comprehensive interfaces supporting diverse sample forms, including liquid, solid, and gaseous, making the analysis process more flexible.
We offer an intuitive interface to simplify data processing and result interpretation, allowing users to focus more on the analysis itself.
Our platform allows users to customize analysis parameters, meeting the special needs and challenges of different projects.

Our Analytical Characterization Services

In the analysis of nucleic acid drugs, our ICP platform is mainly used for:

Particulate Matter Analysis

ICP can detect metal particles and other insoluble particulates in drugs, essential for ensuring drug purity and safety.

Bacterial Endotoxins Testing

While ICP isn't used directly for endotoxin detection, it detects metal ions in samples that may impact bacterial endotoxin test outcomes.

Publication Data

Technology: Analysis of inorganic elements using the ICP-MS technology platform

Journal: Foods

IF: 5.561

Published: 2023

Results:

Fraud in the food industry, driven by rising demand, leads to practices like mislabeling to boost profits, impacting both economy and health. This has spurred a multidisciplinary approach using analytical techniques to authenticate food origins. Among these, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) stands out for tracing inorganic elements in food, crucial for assessing nutritional content and geographic authenticity. Differences in inorganic components help establish origin due to varied matrix compositions in different regions. This literature review compiles research on using ICP-MS for food origin authentication, beginning with a tutorial on food safety and ICP-MS fundamentals, followed by a comprehensive research review.

Fig.2 Diagram illustrating key components of an ICP-MS. Fig.2 Schematic diagram of the main components of an ICP-MS. (Mazarakioti E C, et al., 2022)

If you have any questions regarding the integration of ICP technology into your nucleic acid drug development, CD Formulation welcomes your inquiries and discussions at any time. Our professional team can provide comprehensive technical support and personalized solutions while ensuring your products meet the highest quality and safety standards. Contact us now to drive your project to success!

References

Mazarakioti E C, Zotos A, Thomatou A A, et al. Inductively coupled plasma-mass spectrometry (ICP-MS), a useful tool in authenticity of agricultural products' and foods' origin. Foods, 2022, 11(22): 3705.

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