Liposome Drug Delivery System Development
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Liposomes are a popular and effective type of nanomaterial for drug delivery, known for their biocompatibility, low toxicity, and ability to encapsulate both hydrophilic and hydrophobic molecules. CD Formulation has extensive expertise and many years of experience in providing specialized liposome drug delivery system development, offering tailored solutions for diverse research applications.
About Liposome Delivery Systems
Liposomes are spherical vesicles composed of phospholipid bilayers that can encapsulate a range of drugs, including anticancer agents, antibiotics, siRNA, antisense oligonucleotides, and therapeutic genes. Their structure mimics cell membranes, allowing for efficient drug delivery and extended circulation time.
Fig.1 Schematic presentation of the structure of a typical liposome. (Abbasi H, et al, 2023)
The Mechanism of Liposome-Targeted Drug Delivery
Liposome-based drug delivery utilizes two main mechanisms: passive targeting, which leverages the enhanced permeability and retention (EPR) effect, and active targeting, which involves surface modifications to improve drug specificity and reduce toxicity.
Fig.2 Schematic illustration of the mechanism of passive targeting and active targeting. (Abbasi H, et al, 2023)
Our Liposome Delivery System Development Services
Liposomes are ideal for delivering chemotherapy drugs due to their ability to concentrate at tumor sites while minimizing side effects. We offer a range of solutions, including long-circulating, active-targeting, stimulus-responsive, and cell membrane-coated liposomes to accelerate cancer treatment research.
Researchers are delving deeper into the transmission of genetic material through liposomes; however, the interaction between liposomes and cells remains enigmatic. Liposome-mediated genetic material transfer can face systemic barriers, such as lysosomal degradation, endosomal escape, and nuclear uptake. Therefore, we are committed to assisting our clients in controlling the physical structure and chemical properties of liposomes to ensure successful gene delivery.
Liposomes, bubble-like lipid bilayer structures ranging in size from nanometers to microns, show great promise as carriers for antigens in various delivery systems. Although currently there are limited numbers of liposome vaccines, their use offers the following advantages: protecting the antigen from degradation, carrying both hydrophilic and lipophilic antigens, controlling the release of antigens, enhancing cell uptake, and improving immune responses to specific antigens. By adjusting properties such as size, charge, membrane fluidity, and surface modification, we can optimize targeted delivery of liposomes to specific cells.
The latest advancements in liposome carrier technology present a promising opportunity to surmount the challenge of ocular drug delivery, with improved permeability, enhanced retention, heightened solubility, reduced toxicity, prolonged release time, and targeted drug delivery to the eyes. By examining various ocular drug delivery systems in conjunction with the specific characteristics of the drug, our objective is to assist our clients in developing superior ocular delivery systems.
Our Capabilities for Liposome Delivery System Development
| Techniques & Platforms |
Details |
| Liposome Delivery System Development Platform |
- Development capacity of specific delivery systems. To develop tailored liposome delivery systems optimized for the distinct properties of various API molecules.
- Excellent formulation development ability. We can offer services from the research stage to pilot, and to scale-up.
- Process optimization capability. Optimizing process parameters can help improve product quality.
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| Characterization Platform |
- Physicochemical characterization (particle size, encapsulation efficiency, potential, etc), in vivo characterization, and in vitro characterization.
- Various analytical instruments such as HPLC (including Thermo, Waters, Agilent.), HPLC-MS/MS, Zeiss/GeminiSEM 500, NucleoCounter NC-250 cell viability analyzer, 3D frozen transmission electron microscope Talos L120C G2, Moxi GO II fast flow cytometer, etc.
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Why Choose CD Formulation?
- Pioneering in the Advancement of Liposome Technology. Our cutting-edge liposome technology holds promising applications in various drug delivery fields, such as gene therapy, vaccines, anticancer drugs, and ophthalmic formulations. Through precise control of the structure and composition of liposomes, we can achieve efficient and stable delivery of the active payload.
- Specific Liposome Delivery Technology. For various types of payloads/active ingredients, we meticulously select the most suitable liposome type from a wide range of options and optimize it to create an optimal delivery system.
- An expert team. Our multidisciplinary team, comprising experts in fundamental medicine, molecular biology, chemistry, and pharmacy, has collaboratively developed the liposome delivery system. Utilizing artificial intelligence, the team advances in big data analysis, simulation calculations, and intelligent-assisted design, enhancing our innovative capabilities and problem-solving flexibility.
As a leader in nanoparticles, CD Formulation is committed to developing professional liposome delivery systems and superior liposome products. Please do not hesitate to contact us if you require any assistance.
References
- Abbasi H, Kouchak M, et al. What we need to know about liposomes as drug nanocarriers: an updated review. Advanced pharmaceutical bulletin. 2023 Jan;13(1):7.
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