Gene Therapy for Cancer

One of the biggest risks to world health is cancer, and because of its complexity and diversity, traditional therapies like radiation therapy, chemotherapy, and surgery can sometimes be ineffective. A developing therapeutic approach called gene therapy seeks to treat cancer by deleting, replacing, or repairing damaged genes. In addition to focusing on the tumor cells, this strategy enhances the patient's immune system, which leads to a better treatment effect. We have extensive research and service expertise in developing cancer gene therapy formulations, and CD Formulation is a leader in the creation of gene therapy drugs.

Advantages of Gene Therapy for Cancer

The genomic characteristics of cancer provide the possibility of personalized treatment. By analyzing the genomic information of tumor cells, a treatment plan for a specific type of cancer is issued. Gene therapy can reduce damage to normal cells, reduce side effects, and improve patients' quality of life. In addition, as technology continues to advance, the safety and efficacy of gene therapy continues to improve.

Main Applications of Gene Therapy for Cancer

Cancer targeting gene-viro-therapy (CTGVT)

CTGVT is to insert anticancer genes into oncolytic virus (OV) vectors. By combining the respective advantages of gene therapy and viral therapy, the viral vectors can specifically replicate in tumor cells and kill tumor cells in a targeted manner. By combining the respective advantages of gene therapy and virus therapy, the viral vector itself can specifically replicate in the tumor cells and kill the tumor cells in a targeted manner, and on the other hand, the expression of the exogenous genes it carries can be greatly increased with the replication and proliferation of the viral vector, which can overcome the drawbacks of low transfection efficiency, poor targeting, low expression of anticancer genes, and insufficient killing power of the traditional cancer gene therapy.

RNAi in cancer

RNA interference (RNAi) is a sequence-specific post-transcriptional gene silencing (PTGS) mechanism wherein double-stranded RNA (dsRNA) molecules mute the matching genes at the mRNA level or stop their expression. RNA interference (RNAi) technology is currently being used more and more in cancer research. In tumor therapy, RNAi technology can specifically inhibit the expression of non-normally up-regulated cancer-related genes, so that they are silenced or dormant, and then achieve the purpose of inhibiting the growth of tumor cells.

Immunogene therapy

Immunogene therapy uses genetically modified tumor seedlings or antigen-presenting cells in vitro, or the direct introduction of immunogenes in vivo,to stimulate or enhance the anti-tumor immune function of the human body, so as to achieve the purpose of tumor treatment. Therapeutic genes include tumor-associated antigen genes, cytokine genes, or MHC genes.

Our Capabilities of Gene Therapy in Cancer

• We continue to deepen our efforts in cancer gene therapy and have developed a sound theoretical system.
• We specialize in providing advanced gene editing technologies and solutions and have various technology systems, such as RNA-based editing platforms and high-throughput gene editing screening platforms.
• We provide comprehensive technical support for cancer gene therapy research and have a unique advantage in cancer gene therapy agent development and technical services.
• We have rich service experience in the field of gene therapy research for various diseases and can help researchers develop reliable research programs and accelerate research progress.

Explore Our Gene Therapy Formulation Development for Cardiovascular diseases

CD Formulation is redefining the gold standard in gene therapy formulation development, with each of our experimental protocols validated by real-world data. If you are interested in us, please feel free to contact us.