The thickness oftransdermal formulations not only affects their appearance but is also directlyrelated to their drug release performance and skin fit. CD Formulation has been researching the field of transdermal formulation for decades has richprofessional knowledge and can provide you with professional testing services.
The thickness of transdermal formulations is closely relatedto their drug-release properties. Appropriate thickness can ensure that thedrug is released at a constant rate. A preparation that is too thick may resultin a reduced fit and reduce the penetration efficiency of the drug; a patchthat is too thin may not provide sufficient support, causing the patch to slideor fall off the skin.
Transdermalformulation thickness testing is of vital significance in formulationdevelopment, production, and quality control processes. CD formulation canprovide you with the following services:
Ensure productconsistency and uniformity. By measuring the thickness of transdermal formulation at different locations, we can evaluate whetherthe product is uniform and whether there are defects in varying thicknesses.
Evaluate drugrelease rate. The thickness of transdermal formulation can affect theformulation and release rate of the drug, so we can indirectly evaluate thedrug release performance through thickness testing.
Our transdermal formulation thicknesstesting process is as follows:
Fig.1 Flow chart of transdermal formulation thickness testing (CD Formulation)
Thickness testingof transdermal formulation usually requires the use of some specializedinstruments to ensure the accuracy and reliability of measurement. We canprovide you with the following commonly used transdermal formulation thicknesstesting instruments:
Instrument | Description |
Micrometer | A micrometer is a precision measuring tool capable of measuring the thickness of an object to a few decimal places. |
Mechanical thickness gauge | Thickness gauge is an instrument specially used to measure the thickness of materials. |
Optical thickness gauge | For some transparent transdermal formulations, optical measuring instruments such as laser rangefinders or optical interferometers can be used to measure their thickness. |
Technology: Methods to transdermalformulation thickness testing
Journal: International Journal ofPharmaceutical Investigation
IF: 5.5
Published: 2016
Results: This study is to test and evaluate thethickness, weight change, tensile strength, extensibility, surface pH, watercontent, moisture absorption rate, drug content, folding endurance, swellingrate, in vitro dissolution and in vitro dermal permeability of transdermal formulation.
Table 1 Physicochemical properties of transdermal films (Garima Thakur, et al., 2016)
Transdermal formulation thickness detection is of irreplaceable importance in the preparation development, production and quality control processes. It is not only a key link in quality control, but also directly affects drug release performance, skin fit, and patient experience. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.
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