Transdermal formulations are administered through the skin, and the drug's transdermal efficiency directly impacts the quality and effectiveness of the formulation. Thus, it is crucial to conduct tensile strength testing of transdermal formulations to ensure product quality and performance. CD Formulation can provide professional testing services for transdermal formulation tensile strength.
Transdermal formulations need to maintain their integrity and structural stability during use. Tensile strength testing can assess the resistance of the patch to external forces to determine whether it will remain intact under normal conditions of use to avoid drug leakage or patch damage due to external forces. Tensile strength testing can also indirectly reflect the adhesive properties of transdermal patches, thereby assessing the stability and durability of their drug release. This is of great significance to ensure that the transdermal patch can release drugs continuously and stably during use and exert its efficacy.
At CD Formulation, tensile strength of transdermal formulation can be measured by tensile tester. Specific operations are as follows:
Fig.1 Flow chart of transdermal formulation tensile strength testing (CD Formulation)
Instrument | Description |
Tensile testing machine | Tensile testing machine is a conventional device used to test the properties of materials under tensile conditions. It usually includes a fixture, a loading unit and a data acquisition system. The transdermal patch sample can be clamped between the fixtures and a gradually increasing tension is applied to measure parameters such as tensile strength, tensile modulus and elongation. |
Shear tensile test machine | This test machine combines shear and tensile functions and is suitable for evaluating the properties of transdermal patches under bidirectional tensile. They usually have multifunctional clamps that can achieve forces in different directions. |
Technology: Methods to transdermal formulation tensile strength testing
Journal: International Scholarly Research Network
IF: 4.1
Published: 2011
Results: In the study, different formulations were prepared by varying the grades of HPMC and concentration of PVP K30 by solvent casting method. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, and drug excipient compatibility.
Table 1 Summary of results of regression analysis (Shailesh T. Prajapati, et al., 2011)
CD Formulation offers professional testing service for the tensile strength of transdermal formulation, If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.
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