Transdermal Formulation Surface pH Testing

Inquiry

pH value is one of the important indicators for testing the properties of transdermal patches and is of great significance for understanding the chemical properties, physical properties, and stability of the patches. CD Formulation can provide you with professional transdermal formulation surface pH testing.

About Transdermal Formulation Surface pH Testing

Transdermal patches require direct contact with the skin, so their surface pH has a direct impact on skin irritation. If the pH value of a transdermal patch exceeds the normal pH range of the skin, it may cause dryness, stinging, itching or other uncomfortable reactions. In addition, maintaining the transdermal patch within a certain pH range ensures its stability. A pH value that is too high or too low may lead to changes in the composition of the transdermal patch, drug failure, texture changes, or bacterial growth, thereby affecting the effectiveness and safety of the product.

What Can We Offer

Through transdermal formulation surface pH testing, we can provide you with the following services:

Acid-base properties

By testing the pH value of a transdermal patch, you can understand the acid-base properties of the patch and determine whether it meets the specified range.

Stability

The stability of drugs is related to their pH value. Some drugs have higher stability within a specific pH value range, but may decompose or deteriorate beyond this range.

Our Workflow of Transdermal Formulation Surface pH Testing

Our steps for transdermal formulation surface pH testing are as follows:

Workflow of transdermal patches surface pH testing. Fig.1 Flow chart of transdermal formulation surface pH testing (CD Formulation)

Our Capabilities for Testing Transdermal Formulation Surface pH

Compared with other pH meters, our existing pH meters are more suitable for pH testing in the pharmaceutical industry:

Advantages

Level 0.001, high resolution/accuracy (0.1/0.01/0.001pH; 1/0.1/0.01 mV).

Buffer: 8 groups + 1 customized group, including buffer groups 4.01, 6.86, 9.18.

Calibration: 1-9 points, meeting various calibration needs.

Three endpoint modes (automatic, manual, and time), are suitable for different samples.

GLP measurement, continuous measurement, meeting the needs of long-term automatic measurement work.

Why Choose Us for Transdermal Formulation Surface pH Testing?

We use advanced electrode technology and precise calibration methods to achieve high-precision measurement of solution pH value. Whether it is a strong acid, a strong base or a neutral solution, it can provide accurate and reliable measurement results.
Our detector has a fast response capability and can stably display the pH value of the solution in a short time. This is especially important for application scenarios that require real-time monitoring and control of pH value.

Published Data

Technology: Methods to transdermal formulation surface pH testing

Journal: International Journal of Pharmaceutical Investigation

IF: 0.5

Published: 2016

Results: The present study was designed to prepare transdermal films of CS and MMT polymer composites. The transdermal films were evaluated in terms of thickness, weight variation, tensile strength, extensibility, surface pH, moisture content, percent moisture absorption, drug content, folding endurance, swelling ratio, in vitro dissolution studies and in vitro skin permeation studies.

Table 1 Physicochemical properties of transdermal films (Garima Thakur, et al., 2016)

We test the moisture content percentage of the patch according to the requirements of the drug regulatory agency for transdermal patches to ensure that it meets the requirements of relevant regulations and standards. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

Garima Thakur, Amrinder Singh. Formulation and evaluation of transdermal composite films of chitosan-montmorillonite for the delivery of curcumin. International Journal of Pharmaceutical Investigation. (2016) Vol 6, Issue 1.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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