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Transdermal Formulation Skin Irritation Testing

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Transdermal formulation skin irritation testing is an important method for assessing the irritating reaction caused by transdermal formulations (such as patches, ointments, creams, etc.) when they come into contact with the skin. Such testing is essential to ensure the safety of transdermal formulations, especially during drug development and cosmetic evaluation. CD Formulation can provide you with professional transdermal formulation skin irritation testing.

About Transdermal Formulation Skin Irritation Testing

The primary objective of skin irritation testing for transdermal formulations is to evaluate whether the formulation may induce adverse reactions such as redness, swelling, pain, and itching upon skin contact, thereby determining its safety and suitability. Irritation, a reversible inflammatory response, can result in irreversible tissue damage if not properly assessed. Skin irritation tests are essential for transdermal patches, especially for spray film formulations that quickly form a film in the affected area and may contain volatile solvents potentially irritating to the skin.

Our Skin Irritation Testing Services

Our comprehensive skin irritation testing services for transdermal formulations include:

Human Skin Patch Test

This method involves applying the formulation directly to human skin and observing reactions over a set period, providing a clear indication of how the product performs on human skin.

Animal Model Test

Using animal models (e.g., mice, rats, pigs), we simulate the human skin environment to evaluate the irritability of the formulation. This approach is cost-effective and straightforward.

Fig.1 Comparison of dermal condition before and after administration of transdermal formulation in different test groups. Fig.1 (A) Dermal in a single group before administration. (B) Dermal in a single group at 72 h after administration. (C) Dermal in repeated groups before administration. (D) Dermal in the repeated group at 72 h after the last administration. (Jianzhong Wang, et al. 2017)

In Vitro Skin Test

By using isolated skin tissue from humans or animals, we observe reactions after exposure to the formulation under controlled conditions, minimizing variability due to individual differences.

Our Workflow

The general procedure for transdermal formulation skin irritation testing includes:

Fig.2 Flow chart depicting the workflow of transdermal formulation skin irritation testing at CD Formulation. Fig.2 Flow chart of skin irritation testing (CD Formulation)

Preparation Stage

Selection of appropriate test methods and subjects (human, animal, or isolated skin), along with the preparation of necessary equipment and materials.

Test Phase

Application of the transdermal formulation to the selected test subject or tissue, followed by observation and recording of skin reactions at specified intervals.

Evaluation Phase

Assessment of the irritation grade based on observed reactions, with statistical analysis conducted if required to validate the results.

Why Choose CD Formulation for Skin Irritation Testing?

Advanced testing technology: We use the most advanced skin irritation testing technology, such as human skin patch test, animal model test, and in vitro skin test, which can fully and accurately evaluate the irritation of transdermal formulations.
High-end test equipment: We have advanced test equipment, such as the TD-12AT transdermal diffusion system, which has automatic sampling and rehydration, automatic exhaust bubbles, and other functions, which can significantly improve the efficiency of research and ensure the accuracy of test results.
Extensive experience: We have long experience in skin irritation testing of transdermal formulations and can handle all kinds of complex situations and provide comprehensive testing services.

Published Data

Technology: Technology for Skin Irritation Testing

Journal: Toxicology Reports

IF: 8.0

Published: 2017

Results: The prediction of side effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs in compliance with the Organization for Economic Cooperation and Development guidelines. To assess dermal irritation, rabbits were dermally attached to vitacoxib for 72 h or repeated application. The results showed adverse reactions such as erythema and edema were observed throughout the test. In the skin sensitization test, guinea pigs were sensitized to vitamin, positive, and negative articles for 24 h. No sensitization reaction was shown in the vita coxib and negative groups whereas severe sensitization was observed in the positive group.

CD Formulation boasts a dedicated team of experts who offer researchers timely and specialized technical support to ensure the seamless execution of testing procedures. We craft tailored testing solutions and services to meet the specific requirements of our clients, ensuring that the test outcomes are both relevant and actionable. Should you require any assistance, please do not hesitate to contact us, and our team will be in touch within three working days.

References

Jianzhong Wang, Zhiyuan Li, et al. Evaluation of dermal irritation and skin sensitization due to vitacoxib. Toxicology Reports. Volume 4, 2017, Pages 287-290.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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