CD Formulation has been dedicated to the rheological properties analysis of transdermal formulation for many years, and has professional knowledge in rheology, to help customers with quality analysis of transdermal formulation, and to provide solutions and services for your products.
The rheological properties of transdermal formulation directly affect the rate and efficiency of drug release from the formulation to the skin surface. Through rheological properties analysis, parameters such as viscosity, flow ability, and shear sensitivity of the formulation can be understood to predict and optimize the release behavior of the drug.
At CD Formulation, we can provide the following services in the analysis of rheological properties of transdermal formulation:
By measuring the viscosity of the matrix in the formulation, we can understand the diffusion rate of drug release from a transdermal formulation. A matrix with a higher viscosity can slow the diffusion of the drug, while a matrix with a lower viscosity can release the drug faster.
Drugs in transdermal formulation can only exert their efficacy after entering the systemic circulation through the skin. Rheological properties can affect the contact area and interaction between the drug and the skin, thereby affecting the transdermal absorption efficiency of the drug.
Our transdermal formulation rheological properties analysis process is as follows:
Fig.1 Flow chart of transdermal formulation rheological properties analysis (CD Formulation)
Instrument | Description |
Rotational rheometer | Measures the viscosity, shear stress, shear rate and other parameters of materials, and can simulate different flow conditions. |
Viscometer | Used to measure the viscosity of a liquid, a property within a liquid that prevents its relative flow. Used to measure the viscosity of a liquid, a property within a liquid that prevents its relative flow. |
Dynamic light scattering | Used to analyze the particle size distribution and stability of drugs in transdermal formulations. These parameters may indirectly affect the rheological properties of the formulation. |
Technology: Methods to transdermal formulation rheological properties analysis
Journal: Int. J. of Applied Mechanics and Engineering
IF: 1.3
Published: 2019
Results: In this research, the rheological properties of local and transdermal drug delivery were analyzed with the aim of systematically characterizing the nonlinear rheological behavior and flow characteristics of drugs and drug carriers in local and transdermal drug delivery. To this end, one - and three-dimensional rheological models have been proposed, which can be used to describe drug release through the skin as well as extracellular and interstitial matrix structures. Finally, rheological measurements were made for some commercially available creams and ointments.
Fig.2 Real flow curves and flow curves corresponding to the Ostwald deWaele model. (A. WALICKA*, et al., 2019)
The analysis of rheological properties of transdermal formulation is of great significance in ensuring the effective release of drugs, the stability of preparations, clinical application effects, and meeting personalized treatment needs. CD Formulation can select the appropriate rheological property analysis method based on the type of transdermal formulation, test purpose and laboratory conditions. Multiple methods can also be combined for analysis to obtain more comprehensive and accurate rheological property information. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.
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