A transdermal patch is a drug delivery system that delivers drugs through the skin. It can deliver drugs into the body continuously and stably. After using a transdermal patch, sometimes some of the medicine may remain on the patch or on the skin. CD Formulation can provide you with professional transdermal formulation residual drug analysis.
In order to maintain a relatively stable drug release rate, the drug content in the transdermal patch is usually higher than the delivered dose during use to achieve a clinically effective delivery rate. Since the concentration of the active ingredient may be close to its saturation limit, a large amount of drug will remain in the patch after the product is used, and there is also a risk of drug crystallization during product storage. Excessive residual drugs in patch products increase the possibility of drug abuse.
At CD Formulation, our testing process is generally as follows:
Fig.1 Flow chart of residual drug analysis (CD Formulation)
We have professional testing equipment to provide you with transdermal formulation residual drug analysis services.
Instrument | Description |
Chromatography | Such as high-performance liquid chromatography (HPLC), gas chromatography (GC), etc., which can be used for quantitative and qualitative analysis of drug residues. |
Mass Spectrometry | Combined with chromatography (such as LC-MS, GC-MS) to provide higher sensitivity and specificity. |
Spectroscopy | Such as ultraviolet-visible spectroscopy (UV-Vis), infrared spectroscopy (IR), etc., which can be used for structural identification and quantitative analysis of drugs. |
Technology: Methods to transdermal formulation residual drug analysis
Journal: Chinese Pharmaceutical Affairs
IF: 1.16
Published: 2023
Results: In the study, the characteristics and technological advancements of transdermal patches' dosage forms were reviewed. The research also systematically summarized the quality control indicators of transdermal patches. Key quality indexes such as drug release, transdermal properties, adhesion, cold flow, and drug residue of transdermal patches were thoroughly evaluated.
Transdermal patch drug residue analysis has significant advantages in drug utilization assessment, side effect assessment, and drug development. CD Formulation can provide you with professional transdermal formulation residual drug analysis. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.
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