Transdermal Formulation Moisture Content Percentage Testing

Inquiry

The moisture content percentage in a transdermal patch will affect its physical and chemical stability. By testing the moisture content percentage of a transdermal patch, the stability, adhesion, and safety of the patch can be evaluated. CD Formulation can provide you with professional transdermal formulation moisture content percentage testing.

About Transdermal Formulation Moisture Content Percentage Testing

Moisture content that is too high or too low may cause the patch to deteriorate, change the drug release rate, or degrade the drug, thereby affecting its efficacy and also affecting the adhesive properties of the patch. In addition, excessive moisture content may lead to the growth of microorganisms and increase the risk of infection. Too low a moisture content may cause the patch to become hard and brittle, increasing the risk of skin irritation.

What Can We Offer

We can provide you with a variety of methods for testing the moisture content percentage of transdermal patches:

Karl Fischer titration

Determination of moisture content by electrochemical titration. This method is very sensitive to samples with low water content.

Drying method

The sample is heated to a certain temperature to evaporate the water, and then the moisture content is calculated by measuring the weight change of the sample before and after.

Our Workflow of Transdermal Formulation Moisture Content Percentage Testing

The process of our drying method to detect moisture content percentage is as follows:

Workflow of transdermal formulation moisture content percentage testing. Fig.1 Flow chart of transdermal formulation moisture content percentage testing (CD Formulation)

Our Capabilities for Testing Transdermal Formulation Moisture Content Percentage

Instrument	Description
Karl Fischer	This method has become the preferred method for trace moisture in international standards and is particularly suitable for the detection of samples with low moisture content.
Dew point moisture meter	Mainly used for the determination of trace moisture in permanent gases, easy to operate.
Coulometric moisture meter	Commonly used for the determination of trace moisture in gases, easy to operate and quick to respond.

Why Choose Us for Transdermal Formulation Moisture Content Percentage Testing?

We have professional testing equipment and can provide optimal instruments and methods to handle a variety of sample analyses. The Karl Fischer Moisture Meter provides accurate and precise results in minutes, allowing for fast and precise determination of moisture content up to 100%. Optimized titration cells maintain very low drift values and can determine the moisture content of liquid, solid and gaseous samples.

Published Data

Technology: Methods to transdermal formulation tensile strength testing

Journal: International Scholarly Research Network

IF: 4.1

Published: 2011

Results: In the study, different formulations were prepared by varying the grades of HPMC and concentration of PVP K30 by solvent casting method. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, and drug excipient compatibility.

We test the moisture content percentage of the patch according to the requirements of the drug regulatory agency for transdermal patches to ensure that it meets the requirements of relevant regulations and standards. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

Amandeep Singh and Alka Bali. Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Journal of Analytical Science and Technology. (2016) 7:25.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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