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Transdermal Formulation Moisture Absorption Rate Testing

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The purpose of testing the moisture absorption rate of transdermal formulation is mainly to evaluate the preparation's ability to absorb and retain moisture. By testing the moisture absorption rate of the preparation, the safety and effectiveness of the preparation can be ensured during storage, transportation and use. CD Formulation can provide you with professional moisture absorption testing services for transdermal preparations.

About Transdermal Formulation Moisture Absorption Rate Testing

If the moisture absorption rate of the drug is too high or too low, it may affect the performance of the patch. In addition, patches may be exposed to different humidity conditions during storage and transportation. If the water absorption rate of the preparation is too high, it may cause it to deteriorate or lose its efficacy. By testing the hygroscopicity of a formulation, its stability under different humidity conditions can be assessed to determine appropriate storage and transportation conditions.

What Can We Offer

Our commonly used methods for testing the moisture absorption rate of transdermal formulation are as follows:

Static method

Place a drug sample of known mass in a specific humidity environment (usually using a saturated salt solution or a humidity controller). After a certain period of time, take out the drug sample and weigh it immediately. The moisture absorption rate is determined by calculating the change in weight.

Dynamic method

Weigh the drug sample continuously for a period of time under specific humidity conditions, and then calculate the moisture absorption rate.

Specific gravity method

Put the drug sample in a water-free container and weigh it accurately. Then put the container in a constant humidity environment to reach the relative humidity required by the drug sample. After the drug is fully humidified, take out the container and weigh it again immediately. The moisture absorption rate is calculated by the difference between the two weighing.

Drying method

Dry the drug sample under constant temperature and humidity conditions, then weigh it and calculate the moisture absorption rate.

Our Workflow of Transdermal Formulation Moisture Absorption Rate Testing

Our transdermal formulation moisture absorption rate testing process is as follows:

Workflow of transdermal formulation moisture absorption rate testingFig.1 Flow chart of transdermal formulation moisture absorption rate testing (CD Formulation)

Why Choose Us for Transdermal Formulation Moisture Absorption Rate Testing?

We have a professional technical team and rich testing experience, equipped with advanced testing equipment and instruments, and can accurately and efficiently perform drug moisture absorption testing. Through moisture absorption testing of transdermal preparations, we can help customers predict the physical and chemical changes that may occur in preparations due to changes in humidity during storage and transportation, thereby assessing their long-term stability.

Published Data

Technology: Methods to the testing of moisture absorption rate

Journal: Journal of analytical science and technology

IF: 2.4

Published: 2016

Results: In the study, Evaluation of the prepared films in terms of physical appearance, weight uniformity, thickness uniformity, surface pH, flatness test, water vapor absorption, water vapor transmission, and drug content uniformity suggest that the method employed for formulation of the transdermal patches was reproducible and ensured excellent quality and uniformity in patch characteristics with minimum variability.

Table 1 Data for water vapor absorption studies for the prepared transdermal systems (Amandeep Singh, et al., 2016)

CD Formulation is familiar with the characteristics and testing requirements of various preparations and can develop appropriate moisture absorption rate testing plans according to the needs of different drugs to ensure the accuracy and reliability of experimental results. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

  1. Amandeep Singh, Alka Bali. Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Journal of analytical science and technology. (2016) 7:25.
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