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Transdermal Formulation In Vivo Skin Permeation and Accumulation Study

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As a leader in transdermal drug delivery technology, CD Formulation is committed to providing researchers with support to develop efficient, innovative, and safe transdermal formulations. Our research and development services, specializing in skin permeation and accumulation studies, are designed to optimize drug delivery systems for effective skin penetration.

About Transdermal Formulation In Vivo Skin Permeation and Accumulation Study

Transdermal formulations deliver the drug directly to the treatment target through the skin, not only reducing gastrointestinal interference but also improving the bioavailability of the drug. However, due to the barrier action of the cuticle of the skin, many drugs are difficult to penetrate effectively. The key to transdermal formulations is whether they can effectively penetrate the skin barrier, reach the concentration required for treatment, and maintain a reasonable in the body. Therefore, accurate detection of skin penetration and accumulation is essential to evaluate and enhance formulation effectiveness, ensuring the safety and efficacy of transdermal products.

Fig.1 Illustration of transdermal drug delivery showing skin penetration and drug absorption. Fig.1 Transdermal drug delivery. (Shashank Chaturvedio, et al. 2021)

Our Expertise in Transdermal Studies

Establishment of Animal Models

We utilize animal models with skin structures similar to humans (e.g., pig or rat skin) to simulate the in vivo behavior of transdermal formulations. These models help in understanding drug penetration and accumulation dynamics.

Advanced Transdermal Penetration Detection

Using advanced transdermal diffusion cell technology, combined with high-performance liquid chromatography (HPLC), mass spectrometry (MS), and other analytical means, the penetration rate, penetration depth, and penetration volume of transdermal formulations in the skin were quantitatively detected. At the same time, the distribution of drugs in each layer of the skin was observed by tissue section and staining techniques.

Accumulation Analysis

The accumulation of drugs in the body is detected by collecting blood samples and skin tissue samples from laboratory animals regularly. Emphasis is placed on the retention time, concentration distribution, and possible metabolites of the drug in the skin to evaluate the safety and efficacy of the drug.

Biomarkers and Imaging Technologies

Our team leverages biomarkers and cutting-edge imaging (e.g., Raman spectroscopy, NMR) to monitor and visualize drug dynamics in vivo, offering detailed insights into transdermal behavior.

Our Instrument Platform

Instrument	Description
Transdermal Diffusion Tester	Evaluates drug release and permeability of transdermal formulations.
Raman Spectrometer	Non-destructive and non-invasive analysis of drug distribution within the skin in real-time.
High-Performance Liquid Chromatography (HPLC)	Detects drug content and metabolites in samples, aiding in penetration and accumulation assessment.
Franz Diffusion Cell	Tests transdermal absorption, providing objective insights into the drug release process.

Why Choose CD Formulation for Transdermal Studies?

Cutting-edge skin penetration testing with the latest technology, including LC-MS/MS and Franz diffusion cells.
Extensive experience in pharmacokinetic studies to determine absorption, distribution, metabolism, and excretion (ADME) of transdermal formulations in vivo.
Strong background in pharmacodynamic evaluations using validated animal models.
Rigorous standards for skin irritation and allergy testing to ensure safety compliance.

Published Data

Technology: Technology for In vitro permeation

Journal: Journal of Drug Delivery Science and Technology

IF: 8.0

Published: 2021

Results: The skin has been employed as a route for localized systemic delivery of drugs. However, the Stratum corneum (SC) of the skin acts as a main barrier for the percutaneous absorption of drug molecules. Therefore, in previous years numerous attempts have been made to overcome this barrier either by passive or active methods. The effectiveness of these techniques can be determined by studying the rate and extent of drug absorption into the different layers of skin. The study of drug-skin or drug-vesicle interaction is also critical for the safe and effective development of topical/transdermal drug delivery systems. However, a comprehensive insight into the available models is still a miss. Therefore, the focus of this review article is to provide insight and up-to-date knowledge about the in-vitro (diffusions cells/type of skin employed), ex-vivo (tape-stripping and confocal laser scanning microscopy), in-vivo (microdialysis, dermal open flow microperfusion, in-vivo pharmacokinetic/dynamic assessment) and in-silico models (Quantitative structure-activity-relationship/Quantitative structure permeability relationships and physiologically based pharmacokinetic-pharmacodynamic approaches) for successful clinical translation of topical and transdermal delivery systems.

CD Formulation provides top-tier R&D services for transdermal formulation studies. With a professional technical team and advanced equipment, we help researchers develop effective and safe drug delivery systems. Contact us to discuss your project requirements, and our team will respond within three working days.

References

Shashank Chaturvedi, Anuj Garg. An insight of techniques for the assessment of permeation flux across the skin for optimization of topical and transdermal drug delivery systems. Journal of Drug Delivery Science and Technology. 2021, Volume 62, 102355.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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