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Transdermal Formulation Folding Endurance Testing

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Transdermal formulation folding endurance testing is of great significance to ensure the safety, effectiveness, and stability of the preparations. CD Formulation can provide you with professional transdermal formulation folding endurance testing services.

About Transdermal Formulation Folding Endurance Testing

The folding endurance of a formulation is directly related to its effectiveness and stability. If the formulation is easily broken or deformed after being folded or bent, the active ingredients of the drug may be affected, resulting in reduced efficacy or failure. Through folding endurance testing, it can be ensured that the formulation can maintain its original effectiveness and stability under various conditions, avoid drug leakage or uneven administration, and thus ensure the therapeutic effect.

What Can We Offer

We usually fold the formulation repeatedly under certain conditions and observe changes in its structure, drug release performance, adhesion and appearance to evaluate its folding resistance.

Structural integrity

Evaluate whether the formulation has structural damage such as cracking, delamination, degumming, etc. after being folded multiple times. These damages may affect the sealing properties of the formulation and the uniformity of drug release.

Adhesion

For transdermal formulations that are required to adhere to the skin, folding resistance testing should also include an assessment of their adhesion. Repeated folding may reduce the adhesion of the formulation, causing it to fall off or shift easily on the skin.

Our Workflow of Transdermal Formulation Folding Endurance Testing

Our transdermal formulation folding endurance testing process is as follows:

Workflow of transdermal formulation folding endurance testing.Fig.1 Flow chart of transdermal formulation folding endurance testing (CD Formulation)

Our Capabilities for Testing Transdermal Formulation Folding Endurance

We can provide you with the following commonly used transdermal formulation folding endurance instruments:

Instrument Description
Folding testing machine A folding test machine is a device that can simulate the stress a product will endure during repeated folding. It can simulate the folding conditions that transdermal formulation may suffer in actual use by setting parameters such as folding angle, frequency, and times.
Adhesion tester For transdermal formulations that need to adhere to the skin, an adhesion tester is a commonly used instrument to evaluate their folding resistance.

Why Choose Us for Folding Endurance Testing?

  • Our instruments use precision sensors and data acquisition systems to accurately measure the resistance and damage of materials under bending.
  • Our instruments are not limited to testing folding resistance, but can also perform a variety of tests, such as three-point bending test, four-point bending test, etc., to meet the testing needs of different types of materials.
  • Our instruments have data-saving functions and can automatically measure, count, and print test results. It helps to better analyze and utilize test data.

Published Data

Technology: Methods to transdermal formulation folding endurance testing

Journal: International Journal of Nanomedicine

IF: 8.0

Published: 2022

Results: In the study, different nanocomposite films of HNT and PVA as a drug carriers were developed using a facile and convenient method for the controlled transdermal delivery of propranolol HCl . The physicochemical characteristics were evaluated, including weight and thickness variation, folding endurance, moisture uptake, moisture content, and drug content. The release and permeation behavior of the drug from the system were determined using the Franz diffusion cell.

Table 1 Quality Characteristics and Drug Content Uniformity of Propranolol HCl Nanocomposites (Muhammad Sikandar, et al., 2022)

Transdermal formulation folding endurance testing can help customers optimize the design and manufacturing process of the formulations and improve their quality and performance. CD Formulation can provide professional folding endurance testing based on product types to ensure the scientificity and rationality of the testing process. If you have any needs, please feel free to contact us and our colleagues will reply to you within three working days.

References

  1. Muhammad Sikandar, Muhammad Harris Shoaib, et al. Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation. International Journal of Nanomedicine. 2022:17 3463–3481.
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